Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline  

作　　者：Tao Yu Vadim A.Soloshonok Zhekai Xiao Hong Liu Jiang Wang 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [2]School of Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Organic Chemistry Ⅰ,Faculty of Chemistry,University of the Basque Country UPV/EHU,San Sebastian 20018,Spain [4]IKERBASQUE,Basque Foundation for Science,Bilbao 48013,Spain [5]School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,UCAS,Hangzhou 310024,China [6]Lingang Laboratory,Shanghai 200031,China

出　　处：《Chinese Chemical Letters》2024年第4期99-105,共7页中国化学快报（英文版）

基　　金：the National Key R&D Program of China(No.2022YFA1302900);the National Natural Science Foundation of China (Nos.82130105, 92253305, 82121005, and 22177124);supported by the Lingang Laboratory (Nos.LG-GG-202204–02 and LG202103–04–01)。

摘　　要：Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties, which enable them to exhibit diverse biological activities such as anti-bacterial,anti-oxidant, anti-inflammatory, and anti-tumor properties. Furthermore, Schiff base metal complexes can serve as reagents and catalysts in chemical reactions. This review aims to provide an overview of our recently published studies on Cu(Ⅱ) and Pd(Ⅱ) complexes derived from proline Schiff base ligands. We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral resolution.

关 键 词：Schiff bases Biological activity Tailor-made amino acids Asymmetric synthesis Chiral tridentate ligands Square-planar Cu(Ⅱ)-complexes Square-planar Pd(Ⅱ)-complexes 

分 类 号：TQ460.1[化学工程—制药化工] O641.4[理学—物理化学]