Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label  

作　　者：Lixian Fu Yiyun Tan Yue Ding Weixia Qing Yong Wang 

机构地区：[1]Henan International Joint Laboratory of Medicinal Plants Utilization,College of Chemistry and Molecular Sciences,Henan University,Kaifeng 475004,China [2]School of Basic Medical Science,Henan University,Kaifeng 475004,China

出　　处：《Chinese Chemical Letters》2024年第4期321-323,共3页中国化学快报（英文版）

基　　金：Henan Provincial Science and Technology Research Project (No.232102310369) for financial support。

摘　　要：A novel D–π –A structure and near–infrared fluorescent probe(DCITT) with high polarity sensitivity and membrane targeting was reported. The fluorescent spectra of DCITT were polarity dependent and Stokes shift was greater than 300 nm. Due to its high fluorescence quantum yield, low cytotoxicity and photostability, DCITT could be used as a labeling probe in multicellular organisms. In particular, DCITT effectively distinguished tumor cells from normal cells because it could specifically light up the cancer cells membrane based on strong red fluorescence for a long time. On this basis, a polar–sensitive cell membrane probe is developed to differentiate tumor cells from normal cells, which provides an idea and method for the early diagnosis of tumor at cellular level.

关 键 词：NIR–fluorescent probe Polarity–sensitive BIOIMAGING Targeting cell membrane Differentiate tumor and normal cells 

分 类 号：R318[医药卫生—生物医学工程] O657.3[医药卫生—基础医学]