Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp_(3))-H functionalization  

作　　者：Tong Li Leping Pan Yan Zhang Jihu Su Kai Li Kuiliang Li Hu Chen Qi Sun Zhiyong Wang 

机构地区：[1]Hefei National Center for Physical Sciences at Microscale,Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China [2]Anhui University of Science and Technology,Huainan 232001,China [3]CAS Key Laboratory of Microscale Magnetic Resonance,Department of Modern Physics,University of Science and Technology of China,Hefei 230026,China

出　　处：《Chinese Chemical Letters》2024年第4期340-345,共6页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China (Nos.21772185;22001241);the support from the Science and Technology Major Project of Anhui Province of China (No.201903a07020003);the Science and Technology Major Project of Fuyang of Anhui Province of China(No.FK20208018)。

摘　　要：An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.

关 键 词：ELECTROCHEMICAL METAL-FREE OXAZOLE Oxidant-free 

分 类 号：O626[理学—有机化学]