Catalytic enantioselective N-silylation of sulfoximine  

作　　者：Xingfen Huang Jiefeng Zhu Chuan He 

机构地区：[1]Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen 518055,China [2]Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education,Hangzhou Normal University,Hangzhou 311121,China

出　　处：《Chinese Chemical Letters》2024年第4期352-356,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China (Nos.22122102, 22101120, 22271134);Guangdong Provincial Key Laboratory of Catalysis (No.2020B121201002);Guangdong Pearl River Talent Program (No.2019QN01Y628);Shenzhen Science and Technology Innovation Committee (No.RCJC20221008092723013);Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education (No.KFJJ2022012)。

摘　　要：A rhodium/diphosphine-catalyzed asymmetric cross-dehydrogenative coupling between sulfoximines and dihydrosilanes has been achieved. This is the first report on the enantioselective N-silylation of sulfoximines. The protocol gives access to a variety of Si-stereogenic N-silylated sulfoximines in decent yield(up to 99%) with excellent stereoselectivity(up to 99%), featuring high atom economy, and a cleaner manner with H2as the sole byproduct. The obtained bis-Si-stereogenic monohydrosilane product can be further converted into the corresponding chiral polymer with pendant sulfoximine groups.

关 键 词：N-Silylation of sulfoximine Chiral silylamine Si-stereogenic silanes Si-CADC Asymmetric catalysis 

分 类 号：O621.251[理学—有机化学]