Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates:A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives  

作　　者：Zhiwei Chen Heyun Sheng Xue Li Menghan Chen Xin Li Qiuling Song 

机构地区：[1]Institute of Next Generation Matter Transformation,College of Materials Science&Engineering and College of Chemical Engineering at Huaqiao University,Xiamen 361021,China [2]Fujian University Key Laboratory of Molecule Synthesis and Function Discovery,College of Chemistry,Fuzhou University,Fuzhou 350108,China [3]State Key Laboratory of Organometallic Chemistry and Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2024年第4期367-370,共4页中国化学快报（英文版）

基　　金：Financial support from National Natural Science Foundation of China(Nos.21931013 and 22271105);Natural Science Foundation of Fujian Province(No.2022J02009);Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University;the Instrumental Analysis Center of Huaqiao University for analysis support;the Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University。

摘　　要：A practical method for the construction of difluoromethylene-containing 1,4-thiazine moieties using readily available diethyl bromodifluoromethanephosphonate(BrCF_(2)PO(OEt)_(2))as difluorocarbene precusor has been developed.This transformation features the efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates.A series of structurally novel and functionalized difluoromethylene-containing 1,4-thiazine derivatives were thus synthesized in good yields.

关 键 词：DIFLUOROMETHYLENE Pyridinium 1 4-zwitterionic thiolates 1 4-Thiazine derivatives 

分 类 号：O626[理学—有机化学]