Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing  

作　　者：Hongxia Li Xiyang Wang Du Qiao Jiahao Li Weiping Zhu Honglin Li 

机构地区：[1]Key Laboratory for Precision&Non-traditional Machining Technology of Ministry of Education,Dalian University of Technology,Dalian 116023,China [2]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Chemical Letters》2024年第4期376-381,共6页中国化学快报（英文版）

基　　金：supported by the Shanghai Beyond Limits Manufacturing Project;the National Natural Science Foundation of China(Nos.11502044, U1906233);the Fundamental Research Funds for the Central Universities (No.DUT22JC08);Dalian city supports innovation and entrepreneurship projects for high-level talents (No.2021RD16);Liaoning Province’s Xing Liao Talents Program (No.XLYC2002108)。

摘　　要：Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gasliquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate,gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.

关 键 词：Microfluidic Gas-liquid segmented micromixer Nanoparticle aggregation Shear effect Numerical calculation 

分 类 号：TQ460.1[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]