Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment  

作　　者：Peide Zhu Yangjia Liu Yaoyao Tang Siqi Zhu Xinyang Liu Lei Yin Quan Liu Zhiqiang Yu Quan Xu Dixian Luo Juncheng Wang 

机构地区：[1]State Key Laboratory of Heavy Oil Processing,China University of Petroleum-Beijing,Beijing 102249,China [2]Department of Laboratory Medicine,Dongguan Institute of Clinical Cancer Research,Affiliated Dongguan Hospital,Southern Medical University,Dongguan 523058,China [3]Department of Laboratory Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen 518052,China [4]Institute of Stomatology,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Chinese Chemical Letters》2024年第4期414-419,共6页中国化学快报（英文版）

基　　金：funded by Beijing Natural Science Foundation (Nos.L222109, 3222018);Military Health Care Project(No.22BJZ22);Science Foundation of China University of Petroleum (Nos.2462019QNXZ02, 2462019BJRC007);National Natural Science Foundation of China (Nos.52211530034, 82273236);Guangdong Provincial Basic and Applied Basic Research Foundation (Nos.2022A151522004, 2022A1515220042);Science and Technology Innovation Commission of Shenzhen (Nos.JSGG20210802153410031, JCYJ20220530141609021);Science and Technology Plan of Shenzhen Nanshan District (No.NS016);Discipline Leader Foundation of Huazhong University of Science and Technology Union Shenzhen Hospital (No.YN2021002);Crosswise Project of Daan Gene (No.HXKY2022002)。

摘　　要：Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关 键 词：Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration 

分 类 号：O657.3[理学—分析化学] R730[理学—化学]