核苷酸结合寡聚化结构域样受体家族含热蛋白结构域蛋白3炎症小体介导糖尿病及其并发症相关机制的研究进展  

Research progress on the mechanism of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing protein 3 inflammasomes mediating diabetes and its complications

作　　者：韩晓瑾 谢军瑶 白秀平[2] Han Xiaojin;Xie Junyao;Bai Xiuping(The Second Clinical Medical School of Shanxi Medical University,Taiyuan 030001,China;Department of Endocrinology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二临床医学院,太原030001 [2]山西医科大学第二医院内分泌科,太原030001

出　　处：《中国综合临床》2024年第2期145-152,共8页Clinical Medicine of China

基　　金：山西省科技合作交流专项项目(202204041101008)。

摘　　要：糖尿病是临床上常见的内分泌系统疾病之一,其确切的发病机制至今尚未明确。核苷酸结合寡聚化结构域样受体家族含热蛋白结构域蛋白3(nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3,NLRP3)炎症小体不仅可以被上游信号通路调控激活,在细胞焦亡、凋亡、坏死、自噬等方面发挥重要作用,而且调节下游炎症因子参与疾病的慢性炎症过程。现阐明NLRP3炎症小体在糖尿病及其并发症发病机制或干预中的作用,并提供了新的研究方向,NLRP3炎症小体及其调节的细胞因子或受体可能是糖尿病及其并发症新的诊断或治疗靶点。Diabetes mellitus is one of the common endocrine diseases in clinic,but its exact pathogenesis not yet been clarified.Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(NLRP3)inflammasome can not only be activated by upstream signaling pathways,which plays an important role in pyroptosis,apoptosis,necrosis,autophagy,etc.,but also regulate downstream inflammatory factors to participate in the chronic inflammatory process of diseases.This article elucidates the role of NLRP3 inflammasome in the pathogenesis or intervention of diabetes and its complications,and provides a new direction for research.NLRP3 inflammasome and its regulated cytokines or receptors may be a new diagnostic or therapeutic targets for diabetes and its complications.

关 键 词：糖尿病 并发症 核苷酸结合寡聚化结构域样受体家族含热蛋白结构域蛋白炎症小体 炎症 机制 

分 类 号：R587.2[医药卫生—内分泌]