除草剂莠去津暴露对人类和其他哺乳动物健康影响的研究进展  

Research progress on healthy effects of herbicide atrazine exposure on human and other mammal

作　　者：白亚男 周蓉 邢巍巍 虞悦 戴传超[2] 卜元卿 BAI Yanan;ZHOU Rong;XING Weiwei;YU Yue;DAI Chuanchao;BU Yuanqing(Nanjing Institute of Environmental Sciences,Ministry of Ecology and Environment,Key Laboratory of Pesticide Environmental Assessment and Pollution Control,Ministry of Ecology and Environment,Nanjing Jiangsu,210042,China;Colloge of Life Sciences,Nanjing Normal University,Nanjing Jiangsu,210023,China;Dalian Eco-environmental Affairs Service Center,Dalian Liaoning,116000,China;Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology,Nanjing University of Information Science&Technology,Nanjing Jiangsu,210044,China)

机构地区：[1]生态环境部南京环境科学研究所,国家环境保护农药环境评价与污染控制重点实验室,江苏南京210042 [2]南京师范大学生命科学学院,江苏南京210023 [3]大连市生态环境事务服务中心,辽宁大连116000 [4]南京信息工程大学江苏省大气环境与装备技术协同创新中心,江苏南京210044

出　　处：《职业与健康》2024年第4期547-553,共7页Occupation and Health

基　　金：国家重点研发计划(2018YFC1801105);生态环境部事业费项目(农村与农业环境保护监督管理)。

摘　　要：目的莠去津(Atrazine,ATZ)是一种在世界范围内广泛使用的三嗪类除草剂,在有ATZ使用历史的地区水体中均检测到ATZ的残留。如果长期持续超量使用,环境中ATZ及其主要降解物质会通过食物链转移,对人类及其他哺乳动物的生殖发育、内分泌、神经、免疫与遗传系统有潜在的毒性作用,进而诱发癌症。因此,本文主要综述了ATZ暴露对人类及其他哺乳动物生殖发育、内分泌、神经、免疫、遗传系统以及潜在致癌性影响的研究进展,并展望了ATZ使用的环境健康风险,提出了ATZ的环境管理建议,对于进一步加强ATZ的使用具有重要意义。Objective Atrazine(ATZ)is a triazine herbicide widely used in the world.Residues of ATZ have been detected in water bodies in regions with a history of ATZ use.If it is used in excess for a long time,ATZ and its main degradation substances in the environment will be transferred through the food chain,which has potential toxic effects on the reproductive development,endocrine,nervous,immune and genetic systems of humans and other mammals,and then induce cancer.Therefore,this paper mainly reviews the research progress of ATZ exposure on human and other mammalian reproductive development,endocrine,nervous,immune,genetic system and potential carcinogenicity,and prospects the environmental health risks of ATZ use,and puts forward environmental management suggestions of ATZ,which is of great significance to further strengthen the use of ATZ.

关 键 词：莠去津 环境健康 生殖发育毒性 内分泌干扰 神经毒性 遗传毒性 免疫毒性 致癌性 

分 类 号：R114[医药卫生—卫生毒理学]