活性维生素D对慢性肾脏病患者代谢及肾脏细胞功能的影响  

Effects of the active form vitamin D on metabolism and kidney cell function in patients with chronic kidney disease

作　　者：郭子仪 张紫媛 方敬爱[2] GUO Zi-Yi;ZHANG Zi-yuan;FANG Jing-ai(The First Clinical Medical School of Shanxi Medical University,Taiyuan 030001,China;Department of Nephrology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院肾内科,太原030001

出　　处：《中国血液净化》2024年第4期286-289,共4页Chinese Journal of Blood Purification

摘　　要：维生素D(vitamin D,VD)是一种脂溶性类固醇衍生物,其不足或缺乏影响慢性肾脏病(chronic kidney disease,CKD)患者的钙磷稳态、甲状旁腺激素水平及血糖血脂代谢,从而导致一系列并发症的发生,降低CKD患者的生活质量及生存率。本文将围绕维生素D对慢性肾脏病患者代谢及肾脏细胞功能的作用机制进行综述,为CKD及其并发症的防治提供思路。Vitamin D is a lipid-soluble steroid derivative.Insufficiency or deficiency of vitamin D in patients with chronic kidney disease(CKD)affects calcium-phosphorus homeostasis,parathyroid hormone(PTH)level and glucose and lipid metabolism,leading to the presence of a series of complications,lower quality of life and reduced survival rate in CKD patients.This article reviews the mechanism of vitamin D on metabolism and kidney cell function in CKD patients to provide bases for the prevention and treatment of CKD and its complications.

关 键 词：维生素D 慢性肾脏病 钙磷稳态 甲状旁腺激素 糖脂代谢 

分 类 号：R692[医药卫生—泌尿科学]