三氟甲基取代1,1-二芳基烷烃衍生物的合成:光诱导CF_(3)Br参与的碳碳双键三氟甲基/芳基化反应  

Photoinduced Trifluoromethyl/arylation Reaction of Carbon Carbon Double Bond Involving CF_(3)Br for the Synthesis of CF3-substituted 1,1-Diaryl Alkane Derivatives

作　　者：马然松 毕吉利 胡雨来[2] MA Ransong;BI Jili;HU Yulai(College of Teacher Education,Shenyang Normal University,Shenyang 110034,China;College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China)

机构地区：[1]沈阳师范大学教师教育学院,沈阳110034 [2]西北师范大学化学化工学院,兰州730070

出　　处：《高等学校化学学报》2024年第5期55-63,共9页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:22061037,21662030)资助.

摘　　要：利用光催化与过渡金属催化相结合的协同催化策略,实现了价廉易得的三氟溴甲烷和芳香胺参与的碳碳双键三氟甲基/芳基化反应,合成了一系列具有潜在生物活性的三氟甲基取代的1,1-二芳基烷烃衍生物.探索了以芳香胺为芳基化试剂制备三氟甲基取代1,1-二芳基烷烃衍生物的可能性,丰富了芳基化试剂的种类,明确了芳基化过程进行的条件,并探讨了反应机理.该方法具有反应条件温和、操作简单和底物价廉易得等优点,为含三氟甲基1,1-二芳基烷烃衍生物的合成提供了一种简捷有效的途径.A synergistic catalytic strategy combining photocatalysis and transition metal catalysis was employed to achieve the carbon carbon double bond trifluoromethyl/arylation reaction in which the inexpensive and readily available bromotrifluoromethane and aromatic amines were used as substrates.A series of potentially biologically active CF3-substituted 1,1-diaryl alkane derivatives was synthesized.This work explores the possibility of aromatic amines as arylation reagents,enriches the types of arylation reagents,clarifies the conditions for the arylation process and explores the reaction mechanism.This method has the characteristics of simple operation,low cost and easy availability,providing a concise and effective approach for the synthesis of trifluoromethyl substituted 1,1-diaryl alkanes derivatives.

关 键 词：光催化 三氟溴甲烷 三氟甲基/芳基化 1 1-二芳基烷烃衍生物 

分 类 号：O625.2[理学—有机化学]