B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and hybrid immunity  

作　　者：Dennis Lapuente Thomas H.Winkler Matthias Tenbusch 

机构地区：[1]Institut für klinische und molekulare Virologie,Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-Nürnberg,Schlossgarten 4,91054 Erlangen,Germany [2]Department of Biology,Division of Genetics,Nikolaus-Fiebiger-Center for Molecular Medicine,Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU),Erlangen,Germany [3]Medical Immunology Campus Erlangen,Friedrich-Alexander-Universität(FAU)Erlangen-Nürnberg,Schlossplatz 1,91054 Erlangen,Germany

出　　处：《Cellular & Molecular Immunology》2024年第2期144-158,共15页中国免疫学杂志（英文版）

基　　金：Deutsche Forschungsgemeinschaft(German Research Foundation)-Projektnummer 215346292[Winkler];Bavarian consortium for research on the pandemic disease COVID-19(FOR-COVID)[Tenbusch].

摘　　要：The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech communities to investigate infection-and vaccine-induced immune responses in the context of this pathogen.B-cell and antibody responses are at the center of these investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and the primary target of SARS-CoV-2 vaccine modalities.In addition to absolute levels,nAb longevity,neutralization breadth,immunoglobulin isotype and subtype composition,and presence at mucosal sites have become important topics for scientists and health policy makers.The recent pandemic was and still is a unique setting in which to study de novo and memory B-cell(MBC)and antibody responses in the dynamic interplay of infection-and vaccine-induced immunity.It also provided an opportunity to explore new vaccine platforms,such as mRNA or adenoviral vector vaccines,in unprecedented cohort sizes.Combined with the technological advances of recent years,this situation has provided detailed mechanistic insights into the development of B-cell and antibody responses but also revealed some unexpected findings.In this review,we summarize the key findings of the last 2.5 years regarding infection-and vaccine-induced B-cell immunity,which we believe are of significant value not only in the context of SARS-CoV-2 but also for future vaccination approaches in endemic and pandemic settings.

关 键 词：SARS-CoV-2 neutralizing antibodies memory responses vaccines IGG4 

分 类 号：R392[医药卫生—免疫学]