脑血管疾病风险人群湿证相关特征的流行病学调查  

Epidemiological Investigation of Dampness Syndrome Manifestations in the Population at Risk of Cerebrovascular Disease

作　　者：倪小佳[1,2,3,4,5] 黄海燕 苏晴[3] 徐曜 刘玲玲 邝卓然 李一航 张一开 孟苗苗 郭意欣 杨小波[4,6] 蔡业峰 NI Xiao-Jia;HUANG Hai-Yan;SU Qing;XU Yao;LIU Ling-Ling;KUANG Zhuo-Ran;LI Yi-Hang;ZHANG Yi-Kai;MENG Miao-Miao;GUO Yi-Xin;YANG Xiao-Bo;CAI Ye-Feng(Encephalopathy Center,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120 Guangdong,China;The Translational Research Team on Chinese Medicine for Cerebrovascular Diseases,Guangdong Provincial Academy of Chinese Medical Sciences,Guangzhou 510120 Guangdong,China;The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China;State Key Laboratory of Dampness Syndrome of Chinese Medicine,Guangzhou 510120 Guangdong,China;HUANG Pei-Xin Studio of Renowned Chinese Medicine Practitioners of Guangdong Province,Guangzhou 510120 Guangdong,China;The Research Team on Traditional Chinese Medicine Syndrome,Guangdong Provincial Academy of Chinese Medical Sciences,Guangzhou 510120 Guangdong,China)

机构地区：[1]广东省中医院脑病中心,广东广州510120 [2]广东省中医药科学院中医药防治脑血管病转化医学研究团队,广东广州510120 [3]广州中医药大学第二临床医学院,广东广州510120 [4]省部共建中医湿证国家重点实验室,广东广州510120 [5]黄培新广东省名中医传承工作室,广东广州510120 [6]广东省中医药科学院中医证候研究团队,广东广州510120

出　　处：《广州中医药大学学报》2024年第3期531-539,共9页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20225021);广州市科技计划市校(院)联合资助项目(编号:202102010300);省部共建中医湿证国家重点实验室专项重点项目(编号:SZ2021ZZ07);国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(编号:国中医药办人教函〔2021〕272号);国家中医药管理局高水平中医药重点学科建设项目(中医脑病学);广州中医药大学“双一流”与高水平大学学科协同创新团队重点项目(编号:2021xk26)。

摘　　要：【目的】探究广东地区脑血管疾病风险人群与中医湿证相关的流行病学特征。【方法】采用横断面研究的方法,调查330例广东常住居民脑血管疾病风险相关的临床资料,进行中医湿证诊断、量化评分及脑卒中风险评级,总结湿证分布规律并分析其影响因素。【结果】(1)诊断为湿证的研究对象共306例(占92.73%),风险组诊断为湿证人群的占比为93.82%(258/275),略高于健康组的87.27%(48/55),但差异无统计学意义(χ2=2.91,P=0.112),而风险组的湿证量化得分高于健康组,差异有统计学意义(Z=-2.24,P=0.025)。(2)在具有脑血管疾病危险因素的研究对象中,评价时间(χ2=26.11,P=0.001)、脑卒中风险等级(χ2=8.85,P=0.031)、脑卒中或短暂性脑缺血发作(TIA)病史(χ2=9.28,P=0.015)是脑血管病风险人群湿证等级的影响因素。【结论】湿证是广东地区人群常见的中医证候;具有脑血管疾病危险因素,尤其是脑卒中高风险人群、脑卒中或TIA病史患者,其湿证程度明显增高;未来在广东开展脑卒中预防工作应考虑湿证的评估与干预。Objective To make an epidemiological investigation on traditional Chinese medicine(TCM)dampness syndrome manifestations in the population at risk of cerebrovascular diseases in Guangdong area.Methods A cross-sectional study was conducted to analyze the clinical data related to the risk of cerebrovascular diseases in 330 Guangdong permanent residents.The diagnosis of dampness syndrome,quantitative scoring of dampness syndrome and rating of the risk of stroke were performed for the investigation of the distribution pattern of dampness syndrome and its influencing factors.Results(1)A total of 306(92.73%)study subjects were diagnosed as dampness syndrome.The percentage of dampness syndrome in the risk group was 93.82%(258/275),which was slightly higher than that of the healthy group(48/55,87.27%),but the difference was not statistically significant(χ2=2.91,P=0.112).The quantitative score of dampness syndrome in the risk group was higher than that of the healthy group,and the difference was statistically significance(Z=-2.24,P=0.025).(2)Among the study subjects at risk of cerebrovascular disease,evaluation time(χ2=26.11,P=0.001),stroke risk grading(χ2=8.85,P=0.031),and history of stroke or transient ischemic attack(TIA)(χ2=9.28,P=0.015)were the factors influencing the grading of dampness syndrome in the population at risk of cerebrovascular disease.Conclusion Dampness syndrome is the common TCM syndrome in the population of Guangdong area.The manifestations of dampness syndrome are more obvious in the population with risk factors of cerebrovascular disease,especially in the population at high risk of stroke,and in the population with a history of stroke or TIA.The assessment and intervention of dampness syndrome should be taken into account for future project of stroke prevention in Guangdong.

关 键 词：脑血管疾病 脑卒中 危险因素 湿证 流行病学调查 广东地区 

分 类 号：R255.2[医药卫生—中医内科学] R277.743[医药卫生—中医学]