葛根治疫浅析  

Analysis of kudz uvne root in the treatment of epidemic diseases

作　　者：张文风[1] 罗绍东 ZHANG Wenfeng;LUO Shaodong(Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,长春130117

出　　处：《长春中医药大学学报》2024年第5期478-480,共3页Journal of Changchun University of Chinese Medicine

基　　金：国家社科基金应急管理体系建设研究专项(20VYJ070);吉林省卫生健康委员会项目(2021GW006);吉林省中医药管理局项目张文风名老中医专家传承工作室。

摘　　要：葛根治疫,溯源弥久。性平辛甘,善走表以升阳解肌、通络以生津解毒,多用于诊治温热疫。如徐氏葛根汤,合膏、芩清解少阳阳明邪热,合麻黄透邪外达、截断病势,以治天行热疫之痘疹欲出者;陈氏葛根汤,合荆、桔、翘等轻清扬上之品,以治疫毒蕴结肺胃之疫痧证;《局方》升麻葛根汤,合升麻火郁发之,以治麻疹初起不透者;陈氏升麻葛根汤,合柴、芩、栀疏利清解三焦,以治气滞血热之丹毒证。现代药理,则多从免疫应答、炎症介质角度阐述其解热、抗病毒等治疫机制。通过上述对葛根药性、方剂配伍、药理研究多个角度的系统梳理,探讨其治疫理论及机制,为临床应用及新药开发提供参考依据。Tracing back to its source,kudze uvne root has been used for a long time to treat the epidemic disease.Kudze uvne root has the mild nature,and its taste is both spicy and sweet.It is good at treating relatively superficial diseases for promoting spleen yang and resolving the flesh,and removing obstruction in collaterals for promoting fluid production and detoxication,so it is often used for the diagnosis and treatment of syndrome of warm-heat and pestilent toxin.For example,Xu's gegen decoction combined with gao and Scutellaria baicalensis can dissipate Shaoyang and Yangming evil fever,while Xu's gegen decoction combined with ephedra herb can remove pathogeneses and cut off the disease progression,in order to treat the patients who want to develop Variola due to acute febrile infectious disease;Chen's gegen decoction combined with medicines with a light and uplifting nature such as Schizonepeta,Platycodon grandifl orum,forsythia and so on,is used to treat scarlet fever,where the epidemic toxins accumulate in the lungs and stomach;In"Prescriptions of Pharmacy Bureau",shengma gegen decoction combined with largetrifoliolious bugbane rhizome can treat fire stagnation,in order to treat the early stage of measles without adequate eruption;Chen's shengma gegen decoction combined with radix bupleuri,Scutellaria baicalensis and Gardenia can unblock and clear Sanjiao meridian,in order to treat erysipelas of stagnation of qi and blood stasis.In modern pharmacology,the mechanism of antipyretic and antiviral treatment is mainly elaborated from the perspectives of immune response and inflammatory mediators.Through the systematic review of the medicinal properties,prescription compatibility and pharmacological research of kudze uvne root,this article explores the theory and mechanism in treating epidemic diseases,in order to provide reference for clinical application and new drug development.

关 键 词：葛根 葛根汤 升麻葛根汤 疫病 

分 类 号：R281[医药卫生—中药学]