卵泡液外泌体在卵泡细胞功能调节中的机制研究进展  

Research advances in follicular fluid exosomes as the regulator of follicular cell function

作　　者：李凯全 张婧宜 冒韵东[1] LI Kaiquan;ZHANG Jingyi;MAO Yundong(Center of Reproductive Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院临床生殖中心,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2024年第5期713-718,737,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81671438,81401267)。

摘　　要：卵泡液是卵泡细胞生长发育的内环境,其成分的变化与卵泡细胞的功能状态息息相关。近年来,人们发现在许多生物体液中都存在一种直径为30~150 nm的双层膜囊泡结构——外泌体(exosome),并揭示了它在众多生理病理过程中的媒介作用。研究者也在卵泡液中鉴定出了外泌体成分,并发现它与卵泡细胞的生长发育有着密切的联系,并间接影响了卵母细胞状态,这对评估卵母细胞质量有着重要意义。Follicular fluid is the internal environment where follicular cells grow and proliferate,and the changes of its components are closely related to the functional status of follicular cells.In recent years,it has been found that exosome,a double-layer membrane vesicle with a diameter of about 30-150 nm,exists in many biological fluids,and its mediating role in many physiological and pathological processes has been revealed.The researchers also identified exosomes in follicular fluid and found that they are closely related to the growth and proliferation of follicular cells,indirectly influencing oocyte status,which is important for assessing oocyte quality.

关 键 词：卵泡液 外泌体 胞外囊泡 MIRNA circRNA 卵母细胞 

分 类 号：R714.13[医药卫生—妇产科学]