火针联合低压无针瘢痕内注射复方倍他米松治疗瘢痕疙瘩疗效及对生长因子水平、瘢痕状态的影响  

Effect of Fire Needle Combined with Low-Pressure Needle Free Scar Injection of Compound Betamethasone on Treatment of Keloid and Its Impact on Growth Factor Levels and Scar Status

作　　者：王玉珍[1] 张丽 张平安[1] WANG Yuzhen;ZHANG Li;ZHANG Ping'an(Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China;Shaanxi Provincial Nuclear Industry 215 Hospital,Shaanxi Xianyang 712000,China)

机构地区：[1]陕西中医药大学第二附属医院,陕西咸阳712000 [2]陕西省核工业二一五医院,陕西咸阳712000

出　　处：《现代中医药》2024年第3期83-87,共5页Modern Chinese Medicine

基　　金：陕西省重点研发计划项目(2021SF-408)。

摘　　要：目的观察火针联合低压无针瘢痕内注射复方倍他米松治疗瘢痕疙瘩的效果及对生长因子水平、瘢痕状态的影响。方法选取2021年1月—2022年2月来我院就诊100例瘢痕疙瘩患者,随机分为对照组、治疗组,每组各50例,对照组采用低压无针瘢痕内注射复方倍他米松,治疗组在对照组基础上加火针治疗,对比两组疗效、生长因子水平、瘢痕状态。结果治疗组治疗后总有效率较对照组为高(P<0.05);治疗组治疗后细胞生长因子β1(TGF-β1)、血小板源生长因子(PDGF)、表皮细胞生长因子(EGF)指标水平均较对照组为低,成纤维细胞生长因子(FGF)指标水平较对照组为高(P<0.05);观察组治疗后瘢痕状态评分均较对照组低(P<0.05)。结论火针联合低压无针瘢痕内注射复方倍他米松治疗瘢痕疙瘩疗效明显,可调节生长因子水平,还能改善瘢痕状态,促进其恢复,值得推广。Objective To observe the effect of fire needle combined with low-pressure needle free scar injection of compound betamethasone on the treatment of keloids and its impact on growth factor levels and scar status.Methods 100 patients with scar tissue who visited our hospital from January 2021 to February 2022 were selected and randomly divided into a control group and an observation group,with 50 cases in each group.The control group received low-pressure needle free injection of compound betamethasone into the scar,while the observation group received fire needle treatment in addition to the control group.The therapeutic effects,growth factor levels,and scar status of the two groups were compared.Results The total effective rate of the observation group after treatment was higher than that of the control group(P<0.05);After treatment,the levels of TGF-β1,PDGF,EGF,and other indicators in the observation group were lower than those in the control group,while the levels of fibroblast growth factor(FGF)were higher than those in the control group(P<0.05);The scar status scores of the observation group after treatment were lower than those of the control group(P<0.05).Conclusion The combination of fire needle and low-pressure needle free scar injection of compound betamethasone has a significant therapeutic effect on scar tissue,can regulate growth factor levels,improve scar status,and promote its recovery.It is worth promoting.

关 键 词：火针 低压无针瘢痕内注射 复方倍他米松 瘢痕疙瘩 生长因子水平 瘢痕状态 

分 类 号：R275[医药卫生—中医皮科]