硝酸银硅胶色谱法制备蒙药土木香中土木香内酯和异土木香内酯  

Preparation of Tu Mu Xiang lactone and Iso Tu Mu Xiang lactone in Mongolian Medicine Tu Mu Xiang by Silver Nitrate Silica Gel Chromatography

作　　者：毛婷 毛乐 张屏[3] 张勇[4] MAO Ting;MAO Le;ZHANG Ping;ZHANG Yong(Inner Mongolia Baogang Hospital,Inner Mongolia Baotou 014010,China;Third Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Inner Mongolia Baotou 014010,China;Inner Mongolia Medical University,Hohhot 010110,China;First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Inner Mongolia Baotou 014010,China)

机构地区：[1]内蒙古包钢医院,内蒙古包头014010 [2]内蒙古科技大学包头医学院第三附属医院,内蒙古包头014010 [3]内蒙古医科大学,内蒙古呼和浩特010110 [4]内蒙古科技大学包头医学院第一附属医院,内蒙古包头014010

出　　处：《现代中医药》2024年第3期94-98,共5页Modern Chinese Medicine

基　　金：国家自然科学基金地区项目(81460651)。

摘　　要：目的探讨蒙药土木香中土木香内酯及异土木香内酯的制备方法。方法采用硝酸银硅胶色谱法进行制备。结果得到两个色泽优良、克数较大的结晶化合物,根据其理化性质及波谱技术鉴定为土木香内酯和异土木香内酯。结论硝酸银硅胶色谱法对土木香内酯及异土木香内酯能实现满意分离,且产量大、纯度高、操作简单,是一种高效快速的制备方法,为土木香内酯及异土木香内酯的广泛应用提供精准可靠的参考资料。Objective To explore the preparation methods of Tu Mu Xiang lactone and Iso Tu Mu Xiang lactone in Mongolian medicine.Methods The method was prepared using silver nitrate silica gel chromatography.Results As a result,two crystalline compounds with excellent color and large weight were obtained,and identified as Tu Mu Xiang lactone and Iso Tu Mu Xiang lactone based on their physical and chemical properties and spectroscopic techniques.Conclusion Silver nitrate silica gel chromatography can achieve satisfactory separation of Tu Mu Xiang lactone and Iso Tu Mu Xiang lactone,with high yield,high purity,and simple operation.It is an efficient and rapid preparation method,providing accurate and reliable reference materials for the widespread application of Tu Mu Xiang lactone and Iso Tu Mu Xiang lactone.

关 键 词：硝酸银硅胶色谱法 土木香内酯 异土木香内酯 

分 类 号：R93[医药卫生—生药学]