疏风清热方雾化对脂质异常型干眼患者瞬目相关视觉质量的影响  

Influence of Shufeng Qingre Formula Nebulization on Blink-related Visual Quality in Patients with Lipid Abnormality-related Dry Eye

作　　者：叶照达 陈凯铭 陈子扬 胡俊[1] 胡艳红[1] 陈胜[1] 周小月 YE Zhaoda;CHEN Kaiming;CHEN Zi-yang;HU Jun;HU Yanhong;CHEN Sheng;ZHOU Xiaoyue(The Second Af-filiated Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350003,China)

机构地区：[1]福建中医药大学附属第二人民医院,福州350003 [2]福建省中医药科学院,福州350003

出　　处：《中国中医眼科杂志》2024年第5期408-413,共6页China Journal of Chinese Ophthalmology

基　　金：福建省中青年教师教育科研项目(JAT210166)。

摘　　要：目的观察疏风清热方雾化对脂质异常型干眼患者瞬目相关视觉质量的影响。方法纳入2022年1月—2023年1月福建中医药大学附属第二人民医院眼科诊治的脂质异常型干眼患者72例,证属风热证。随机分为对照组和观察组各36例。对照组予羟糖甘滴眼液治疗,观察组在对照组的基础上联合疏风清热方雾化治疗。2组均治疗4周。分别于治疗前、后检测患者的眼表疾病指数(OSDI)评分、非侵入性首次泪膜破裂时间(NIF-BUT)、非侵入性平均泪膜破裂时间(NIAVG-BUT)、视觉质量各阶像差,记录数据并做统计分析。结果2组治疗前OSDI评分、NIF-BUT、NIAVG-BUT、瞬目后0 s和10 s获取的视觉质量比较,差异均无统计学意义(P>0.05)。(1)OSDI评分:2组治疗后OSDI评分均较治疗前降低,差异均有统计学意义(t_(观察组)=7.740,P=0.000;t_(对照组)=2.619,P=0.010)。治疗后2组间比较,观察组OSDI评分低于对照组,差异有统计学意义(t=6.668,P=0.000)。(2)NIF-BUT、NIAVG-BUT:2组治疗后NIF-BUT(Z_(观察组)=7.374、Z_(对照组)=11.237,均P=0.000)、NIAVG-BUT(Z_(观察组)=5.940、Z_(对照组)=3.408,均P=0.000)均较治疗前延长,差异均有统计学意义。治疗后2组间比较,观察组NIFBUT、NIAVG-BUT均长于对照组,差异均有统计学意义(Z_(NIF-BUT)=5.892、Z_(NIAVG-BUT)=6.949,均P=0.000)。(3)瞬目后0 s获取的视觉质量:2组治疗后总HOAs均方根(Z_(观察组)=6.489、Z_(对照组)=3.306,均P=0.000)、四阶球差(Z_(观察组)=7.961、Z_(对照组)=4.026,均P=0.000)、三阶彗差(Z_(观察组)=5.008、Z_(对照组)=4.170,均P=0.000)、三叶草差(Z_(观察组)=5.669、Z_(对照组)=3.410,均P=0.000)均较治疗前降低,差异均有统计学意义。治疗后2组间比较,观察组各像差均低于对照组,差异均有统计学意义(Z_(总HOAs)=4.735、Z_(四阶球差)=6.578、Z_(三阶彗差)=4.055、Z_(三叶草差)=3.846,均P=0.000)。(4)瞬目后10 s获取的视觉质量:2组治疗后总HOAs均方根(Z_(观�OBJECTIVE To observe the Shufeng Qingre Formula nebulization on blinkrelated visual quality in patients with lipid abnormality-related dry eye.METHODS A total of 72 patients diagnosed with lipid abnormality-related dry eye,characterized by wind-heat pattern,were included from January 2022 to January 2023 at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine.They were randomly divided into a control group(CG)and an observation group(OG),each comprising 36 cases.The control group received treatment with hydroxypropyl guar eye drops,while the observation group received combined treatment of Shufeng Qingre Formula nebulization in addition to the treatment provided in the control group.Both groups were treated for four weeks.Ocular Surface Disease Index(OSDI)scores,non-invasive first break-up time(NIF-BUT),non-invasive average break-up time(NIAVG-BUT),order aberrations of visual quality measured and statistically analyzed before and after treatment.RESULTS Before treatment,there were no significant differences in OSDI scores,NIF-BUT(NB),NIAVG-BUT(NIB),and visual quality at blink 0 s and 10 s between the two groups(P>0.05).(1)OSDI scores:After treatment,OSDI scores in both groups decreased significantly compared to before treatment(t_(OG)=7.740,P=0.000;t_(CG)=2.619,P=0.010).The observation group had lower OSDI scores than the control group after treatment(t=6.668,P=0.000).(2)NIF-BUT,NIAVG-BUT:After treatment,both NIF-BUT and NIAVG-BUT in both groups prolonged significantly compared to before treatment(NIF-BUT:Z_(OG)=7.374,Z_(CG)=11.237,both P=0.000;NIAVG-BUT:Z_(OG)=5.940,Z_(CG)=3.408,both P=0.000).The observation group had longer NIFBUT and NIAVG-BUT than the control group after treatment(Z_(NB)=5.892,Z_(NIB)=6.949,both P=0.000).(3)Visual quality at blink 0 s:After treatment,all order aberrations of visual quality decreased significantly in both groups compared to before treatment[total HOAs(TH):Z_(OG)=6.489,Z_(CG)=3.306,both P=0.000;fourth-order spherical aberration(FOSA):Z_(OG)=7.961,

关 键 词：疏风清热方 脂质异常型干眼 瞬目 视觉质量 高阶像差 

分 类 号：R276.7[医药卫生—中医五官科学]