盐酸纳布啡、地佐辛分别复合丙泊酚在青光眼小梁切除术中的应用比较  

Comparison of the application of nabuprofen hydrochloride or dezocine combined with propofol in trabeculectomy for glaucoma

作　　者：刘莉红[1] 理珊珊 LIU Lihong;LI Shanshan(Department of Anesthesiology,Ophthalmic Operating Room the Second People's Hospial of Zhengzhou,Henan 450000)

机构地区：[1]郑州市第二人民医院眼科手术室麻醉科,河南郑州450000

出　　处：《实用防盲技术》2024年第2期62-66,61,共6页Journal of Practical Preventing Blind

摘　　要：目的 比较盐酸纳布啡、地佐辛分别复合丙泊酚在青光眼小梁切除术中的应用效果。方法 将86例择期行小梁切除术的青光眼患者随机分为对照组和观察组,对照组采用地佐辛复合丙泊酚麻醉,观察组采用盐酸纳布啡复合丙泊酚麻醉;比较两组患者麻醉前5min (T0)、麻醉后5min (T1)、手术开始5min (T2)、手术完成后(T3)生命体征变化情况,另比较两组T0、T1的眼压以及麻醉苏醒、术后疼痛和镇静及不良反应发生情况。结果观察组T1、T2时的平均动脉压、心率、脉搏血氧饱和度均大于对照组(T1:t=3.469、2.536、3.761,T2:t=2.357、2.213、2.686,均P<0.05);两组T1时眼压均低于T0时(t=13.492、11.507,均P<0.05),但两组T0、T1时的眼压比较差异无统计学意义(P>0.05);观察组的拔管时间、呼吸恢复时间、麻醉苏醒时间均短于对照组(t=4.466、3.237、4.975,均P<0.05),术中丙泊酚追加量少于对照组(t=6.645,P<0.05);观察组术后6h的NRS评分低于对照组(t=6.540,P<0.05),两组Ramsay镇静评分比较差异无统计学意义(P>0.05);观察组心动过缓及呼吸抑制的发生率均低于对照组(P<0.05)。结论 盐酸纳布啡复合丙泊酚用于青光眼小梁切除术时患者生命体征稳定性、麻醉恢复情况及术后镇痛情况均优于地佐辛复合丙泊酚,且患者不良反应发生率较低。Objective To compare the application effect of nabuprofen hydrochloride or dezocine combined with propofol in trabeculectomy for glaucoma.Methods 86 glaucoma patients who underwent elective trabeculectomy were randomly divided into control group and observation group.The control group was anesthetized with dezocine combined with propofol,while the observation group was anesthetized with nabuprofen hydrochloride combined with propofol.The changes in vital signs of two groups at 5 minutes before anesthesia(TO),5 minutes after anesthesia(T1),5 minutes after surgery begins(T2)and 3 minutes after surgery completion(T3)were compared,and the intraocular pressure at TO and T1,anesthesia recovery,postoperative pain and sedation and adverse reaction in two groups of patients were compared.Results The mean arterial pressure,heart rate and pulse oxygen saturation of the observation group at T1 and T2 were higher than those of the control group(T1:t=3.469、2.536、3.761,T2:t=2.357、2.213、2.686,all P<0.05);The intraocular pressure at T1 was lower than that at T0 in both groups(t=13.492、11.507,all P<0.05),but there was no statistically significant difference in intraocular pressure between the two groups at TO and T1(P>0.05).The extubation time,respiratory recovery time and anesthesia recovery time of the observation group were shorter than those of the control group(t=4.466、3.237.4.975,all P<0.05),while the additional amount of propofol during surgery was less than that of the control group(t=6.645,P<0.05);The NRS score of the observation group at 6 hour after surgery was lower than that of the control group(t=6.540,P<0.05),and there was no statistically significant difference in Ramsay sedation scores between the two groups(P>0.05);The incidence of bradycardia and respiratory depression in the observation group were lower than those in the control group(P<0.05).Conclusion The stability of vital signs,recovery of anesthesia,and postoperative analgesia of patients undergoing trabeculectomy with nabuprofen hydrochloride

关 键 词：盐酸纳布啡 地佐辛 丙泊酚 青光眼 小梁切除术 

分 类 号：R614[医药卫生—麻醉学]