仿生矿化透明质酸钠复合材料的制备及其性能分析  

Preparation of biomimetic mineralized sodium hyaluronate composites and the analysis of their properties

作　　者：陈思颖 谢番 赵瑞波[1] 孔祥东[1] CHEN Siying;XIE Fan;ZHAO Ruibo;KONG Xiangdong(School of Materials Science&Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China)

机构地区：[1]浙江理工大学材料科学与工程学院,杭州310018

出　　处：《浙江理工大学学报（自然科学版）》2024年第3期292-299,共8页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：国家自然科学基金项目(51902289);浙江省自然科学基金项目(LQ19E020010)。

摘　　要：为了提升透明质酸钠(Sodium hyaluronate,SH)的力学性能,采用仿生矿化方法,将磷酸钙寡聚体(Calcium phosphate oligomers,CPO)与SH复合形成透明质酸钠复合材料(SH-CPO),对SH-CPO的形貌、结构、流变学特性及压缩性能进行了测试与表征。结果表明:SH不仅与CPO具有良好的相互作用,能形成内部结构连续的复合材料,还能诱导CPO发生从无定形到结晶相的转变;在SH与CPO的质量比为1∶1~1∶10范围内,随着CPO投料比例的增加,制备的SH-CPO复合材料的黏度得到提升,压缩强度可达到53.5 MPa。该研究制备的SH-CPO复合材料具有良好的力学性能,在生物医学材料领域中具有良好的应用潜力。To improve the mechanical properties of sodium hyaluronate(SH),calcium phosphate oligomers(CPO)were combined with SH to form sodium hyaluronate composites(SH-CPO)by biomimetic mineralization method.The morphology,structure,rheological and compressive properties of the composites were characterized and tested.The results showed that SH interacted well with CPO and could form composites with continuous internal structure,inducing the transformation of CPO from amorphous to crystalline phase.In the 1∶1~1∶10 mass ratio range of SH to CPO,with the increase of CPO content,not only the viscosity of the prepared SH-CPO composites was improved,but also the compressive resistance could reach 53.5 MPa.The SH-CPO composites prepared in this study have good mechanical properties and application potential in biomedical materials.

关 键 词：仿生矿化 透明质酸钠 磷酸钙寡聚体 复合材料 力学性能 

分 类 号：TB33[一般工业技术—材料科学与工程]