丝素-聚苯胺复合纳米纤维膜的制备及其性能  

Preparation and antibacterial properties of silk fibroin-polyaniline composite nanofiber membranes

作　　者：周家宝 刘涛[1] 仇巧华 朱灵奇 王艳敏 丁新波[1] ZHOU Jiabao;LIU Tao;QIU Qiaohua;ZHU Lingqi;WANG Yanmin;DING Xinbo(College of Textile Science and Engineering(International Institute of Silk),Zhejiang Sci-Tech University,Hangzhou 310018,China)

机构地区：[1]浙江理工大学纺织科学与工程学院(国际丝绸学院),杭州310018

出　　处：《现代纺织技术》2024年第5期9-17,共9页Advanced Textile Technology

基　　金：国家自然科学基金项目(37900964);浙江理工大学科研启动基金项目(11150131722120)。

摘　　要：以再生丝素蛋白(SF)为原料,以聚苯胺(PANI)为功能添加剂,采用静电纺丝技术制备了丝素-聚苯胺(SF-PANI)复合纳米纤维膜。通过SEM、XRD和FTIR等对其形貌、结构和性能进行表征。结果表明:SF-PANI复合纳米纤维膜孔隙率在70%以上;在磷酸盐缓冲液中其溶胀度可达158%;最大拉伸应力可达2.5 MPa。当SF-PANI复合纳米纤维膜中PANI质量分数为5%时,对大肠杆菌的抑菌率为80.08%,对金黄色葡萄球菌的抑菌率为75.20%;对PANI质量分数为5%的SF-PANI复合纤维膜进行卤化处理后,其对金黄色葡萄球菌及大肠杆菌的抑菌率均能达到100%。该复合膜具有良好的理化性能和抗菌性能,在抗菌型生物材料方面具有一定的应用前景。This article used electrospinning technology to prepare composite antibacterial(SF PANI) dressings with polyaniline(PANI) and regenerated silk fibroin(SF) as raw materials.Silk fibroin is a structural protein that is spun into fibers by thousands of arthropods and used in vitro.It is a natural high molecular fiber protein and is often used as an ideal dressing for repairing oral,maxillofacial,and systemic skin wounds.The modification of silk fibroin materials with different antibacterial properties has received extensive research and attention.Finished silk fibroin is obtained by degumming,dialysis,and freeze-drying of silkworm cocoons.Due to the easy availability of raw materials,diverse chemical structures,simple synthesis methods,unique doping mechanisms,low cost,and good biological stability,polyaniline functionalized derivatives are a new type of antibacterial agent with the potential to provide anti-fouling surfaces as non-leaching additives,and have broad prospects in textile-based flexible applications.Electrospinning is a simple,cost-effective,and controllable method for preparing nanofibers or microfibers from polymers in solution or melt state under high voltage electric fields.Through scanning electron microscopy(SEM),it can be seen that as the PANI content in the SF-PANI composite nanofiber membrane increases,the fiber diameter of the composite membrane gradually decreases from a microscopic perspective,and becomes more and more uneven in thickness.From a macro perspective,with the increase of PANI content,the overall color of the nanocomposite fiber membrane changes from pure white to dark green.The chemical composition and structure of PANI were characterized by instruments such as infrared spectroscopy(FTIR) and X-ray powder diffraction(XRD).It was found that PANI was successfully loaded on the SF fiber membrane,and the addition of PANI did not react with SF to produce a new chemical structure.By analyzing the swelling and porosity of the SF-PANI composite fiber membrane,it can be concluded that t

关 键 词：聚苯胺 丝素蛋白 静电纺丝 卤化处理 抗菌性能 

分 类 号：TB332[一般工业技术—材料科学与工程]