妊娠期高血压疾病患者孕晚期血清FGF2和VEGF表达与胎儿生长受限的相关性分析  

The Correlation Analysis Between Expressions of Serum FGF2 and VEGF in Late Pregnancy Hypertensive Disorders of Pregnancy Patients and Fetal Growth Restriction

作　　者：于雪梅 方建红 梁金丽 杨燕 YU Xuemei;FANG Jianhong;LIANG Jinli;YANG Yan(Obstetrics Department,Chengyang District People’s Hospital,Qingdao 266109,China)

机构地区：[1]山东省青岛市城阳区人民医院产科,山东青岛266109

出　　处：《标记免疫分析与临床》2024年第4期698-702,735,共6页Labeled Immunoassays and Clinical Medicine

基　　金：青岛市2018年度医药科研指导项目(编号:2018-WJZD141)。

摘　　要：目的探究妊娠期高血压(HDP)疾病患者孕晚期血清成纤维细胞生长因子2(FGF2)和血管内皮生长因子(VEGF)表达与胎儿生长受限(FGR)的相关性。方法收集2022年1月至2022年12月在我院分娩的60例孕晚期HDP并发FGR孕妇(FGR组)、60例HDP孕妇未发生FGR孕妇(HDP组)临床资料,并以同期60例健康孕产妇作为对照组。血清FGF2、VEGF水平测定使用酶联免疫吸附法(ELISA);比较HDP组、FGR组及对照组孕妇血清FGF2、VEGF水平;采用Logistic回归分析影响FGR发生的因素;Pearson相关性分析血清FGF2、VEGF水平与新生儿体质量间的关系;受试者工作特征曲线(ROC)探究血清FGF2、VEGF表达对FGR的预测效能。结果3组在年龄、孕周、BMI、分娩方式上差异无统计学意义(P>0.05),在收缩压、舒张压、新生儿体质量上差异有统计学意义(P<0.05);与对照组相比,HDP组、FGR组血清FGF2水平升高(P<0.05),VEGF水平降低(P<0.05),且FGR组孕妇血清FGF2水平高于HDP组(P<0.05),VEGF水平低于HDP组(P<0.05);Logistic回归分析显示,收缩压、舒张压、血清FGF2、VEGF水平均是孕晚期HDP孕妇发生FGR的独立影响因素(P<0.05);ROC曲线结果显示,FGF2、VEGF诊断HDP孕妇发生FGR的AUC分别为0.850、0.849,灵敏度分别为76.7%、86.7%,特异性分别为60.0%、60.0%,两者联合诊断孕晚期HDP孕妇发生FGR的AUC为0.933,灵敏度为88.3%,特异性为76.6%。结论发生FGR的孕晚期HDP孕妇血清FGF2水平升高,VEGF水平降低,两者为孕晚期HDP孕妇发生FGR的危险因素,且对FGR具有一定的预测价值。Objective To investigate the relationship between expressions of serum fibroblast growth factor 2(FGF2),vascular endothelial growth factor(VEGF)and fetal growth restriction(FGR)in patients with hypertensive disorders of pregnancy(HDP).Methods Clinical data of 60 late pregnancy HDP complicated with FGR pregnant women(FGR group)and 60 HDP pregnant women without FGR(HDP group)who delivered in our hospital from January,2022 to December,2022 were collected for the study,while 60 healthy pregnant women during the same period were enrolled the control group.Serum FGF2 and VEGF levels were determined by enzyme linked immunosorbent assay(ELISA);Levels of serum FGF2 and VEGF were compared among pregnant women from the HDP group,FGR group,and control group;The influencing factors of FGR were identified by logistic regression;The relationship between serum FGF2,VEGF levels and neonatal body mass was analyzed by Pearson correlation method;The predictive value of serum of serum FGF2 and VEGF expression on FGR was investigated by receiver operating characteristic curve(ROC).Results There was no statistically significant difference in age,gestational age,BMI,and delivery method among the three groups(P>0.05),but there was a statistically significant difference in systolic blood pressure,diastolic blood pressure,and neonatal body mass(P<0.05);Compared with the control group,the serum FGF2 level increased(P<0.05)while VEGF level decreased(P<0.05)in the HDP and FGR groups,and the serum FGF2 level was higher(P<0.05)and VEGF level was lower in the FGR group than that in the HDP group;Logistic regression analysis indicated that systolic blood pressure,diastolic blood pressure,serum FGF2,VEGF levels were all independent influencing factors for FGR in late pregnancy HDP pregnant women(P<0.05);Receiver operating characteristic curve showed that the AUC of FGF2 and VEGF for predicting FGR in HDP pregnant women in the late pregnancy were 0.850 and 0.849,respectively,with the sensitivity of 76.7%,86.7%,and the specificity of 60.0%and 60.0%,

关 键 词：妊娠高血压 胎儿生长受限 成纤维细胞生长因子2 血管内皮生长因子 相关性 

分 类 号：R714.252[医药卫生—妇产科学]