HBeAg阳性CHB患者血清白介素-8与聚乙二醇化干扰素-α治疗的关系  

Association of serum interleukin-8 with pegylated interferon-αtreatment in HBeAg-positive chronic hepatitis B patients

作　　者：杨凯 施维 孙蓓蓓[2] 潘颖 陈谨[1] YANG Kai;SHI Wei;SUN Bei-bei(Anhui Medical College,Hefei 230601,Anhui;The Second Hospital of Anhui Medical University,Hefei 230601,Anhui)

机构地区：[1]安徽医学高等专科学校,安徽合肥230601 [2]安徽医科大学第二附属医院,安徽合肥230601

出　　处：《安徽医专学报》2024年第2期18-20,23,共4页Journal of Anhui Medical College

基　　金：安徽省自然科学基金(编号:2108085MH301);安徽省教育厅省级教学质量工程项目(编号:2022jnds028)。

摘　　要：目的:探讨血清白介素-8(IL-8)能否作为预测因子评估HBeAg阳性慢性乙型肝炎(CHB)患者接受聚乙二醇化干扰素-α(PEG-IFN-α)抗病毒治疗的疗效。方法:通过接受PEG-IFN-α抗病毒治疗48周的53例HBeAg阳性CHB患者,分析比较非持续应答患者和持续应答患者血清IL-8基线和治疗48周时含量差异,并分析患者血清IL-8基线与临床特征的相关性。采用受试者工作特征曲线(ROC)评估血清IL-8基线含量在预测PEG-IFN-α抗病毒疗效的临床价值。结果:与非持续应答患者血清IL-8含量(181.68±84.43)pg/mL相比较,持续应答患者血清IL-8基线含量(124.81±74.12)pg/mL显著降低。经48周PEG-IFN-α抗病毒治疗后,持续应答患者血清IL-8含量也显著降低,而非持续应答患者血清IL-8含量变化不显著。非持续应答患者和持续应答患者的血清IL-8基线含量均与HBsAg、HBeAg和HBV-DNA呈正相关,但相关性强弱有差异。血清IL-8基线含量预测HBeAg阳性CHB患者接受PEG-IFN-α治疗的持续应答的曲线下面积为0.711。结论:血清IL-8基线含量高低影响PEGIFN-α治疗HBeAg阳性CHB患者的抗病毒疗效,是潜在的临床预测指标。Objective:To investigate whether serum interleukin-8(IL-8)can be used as a predictor to evaluate the efficacy of pegylated interferon-α(PEG-IFN-α)antiviral therapy in HBeAg-positive chronic hepatitis B(CHB)patients.Methods:53 HBeAg-positive CHB patients received PEG-IFN-αantiviral therapy for 48 weeks.Serum IL-8 levels were compared between patients who achieved non-response and patients who achieved sustained response at baseline and 48 weeks of treatment,and the correlation between baseline serum IL-8 and clinical characteristics was analyzed.Receiver operating characteristic curve(ROC)to evaluate the clinical value of serum IL-8 at baseline in predicting the antiviral efficacy of PEG-IFN-α.Results:Serum level of IL-8 at baseline(181.68±84.43 pg/mL)was significantly lower in patients who achieved sustained response than in patients who achieved non-response(124.81±74.12 pg/mL).After 48 weeks of PEG-IFN-αantiviral treatment,the serum level of IL-8 in patients with continuous response was also significantly decreased,while the serum level of IL-8 in patients who achieved sustained response was not significantly changed.The serum level of IL-8 at baseline was positively correlated with HBsAg,HBeAg and HBV-DNA in both two groups of patients,but the correlations were different.Baseline serum level of IL-8 predicted a sustained response to PEG-IFN-αtherapy in HBeAg-positive CHB patients with an area under the curve of 0.711.Conclusion:Serum level of IL-8 at baseline influences the antiviral efficacy of PEG-IFN-αin the treatment of HBeAg-positive CHB patients,and is a potential clinical predictor.

关 键 词：慢性乙型肝炎 白介素-8 聚乙二醇化干扰素-α 抗病毒疗效 

分 类 号：R446.1[医药卫生—诊断学]