乌司他丁治疗新生儿坏死性小肠结肠炎的疗效及对血清Galectin-3及IGF-1的影响  

Efficacy of Ulinastatin in the Treatment of Neonatal Necrotizing Enterocolitis and the Effect on Serum Galectin-3 and IGF-1

作　　者：肖二明 Xiao Erming(Department of Neonatology,Langfang Maternal and Child Health Hospital,Langfang 065000,Hebei Province,China)

机构地区：[1]廊坊市妇幼保健院新生儿科,河北廊坊065000

出　　处：《中外医药研究》2024年第7期39-41,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：廊坊市科技局科研项目(编号:2023013059)。

摘　　要：目的:分析乌司他丁治疗新生儿坏死性结肠炎(NEC)的疗效及对血清半乳糖凝聚素3(Galectin-3)与胰岛素样生长因子-1(IGF-1)的影响。方法:选取2019年1月—2021年2月廊坊市妇幼保健院收治的NEC患儿80例作为研究对象,依据随机数字表法分为观察组与对照组,各40例。对照组行双歧乳杆菌三联活菌片治疗,观察组应用乌司他丁治疗。比较两组总有效率及肿瘤坏死因子α(TNF-α)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、Galectin-3、IGF-1水平。结果:观察组总有效率高于对照组,差异有统计学意义(P=0.012);治疗后,两组患儿TNF-α、IL-8、CRP水平均降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组患儿Galectin-3水平均下降,IGF-1水平均升高,且观察组优于对照组,差异有统计学意义(P<0.05)。结论:应用乌司他丁治疗NEC患儿可取得较理想的临床疗效,其能够有效抑制炎性因子与Galectin-3,提高IGF-1水平,值得临床推广。Objective:To analyze the efficacy of ulinastatin in the treatment of neonatal necrotizing enterocolitis(NEC)and the effects on serum galectin-3(Galectin-3)and insulin-like generating factor-1(IGF-1).Methods:Eighty cases of children with NEC admitted to Langfang Maternal and Child Health Hospital from January 2019 to February 2021 were selected as the study subjects,and were divided into the observation group and the control group based on the randomized numerical table method,each with forty cases.The control group was treated with Lactobacillus bifidum triple viable tablets,and the observation group was treated with ulinastatin.The total effective rate and the levels of tumor necrosis factor alpha(TNF-α),interleukin-8(IL-8),C-reactive protein(CRP),Galectin-3 and IGF-1 were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.012);after the treatment,the levels of TNF-α,IL-8,and CRP were reduced in both groups,and the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,Galectin-3 levels decreased and IGF-1 levels increased in both groups,and the observation group was better than the control group,with statistically significant differences(P<0.05).Conclusion:The application of ulinastatin in the treatment of NEC children can achieve better clinical efficacy,which can effectively inhibit inflammatory factors and Galectin-3,and increase the level of IGF-1,which is worthy of clinical promotion.

关 键 词：乌司他丁 新生儿坏死性小肠结肠炎 半乳糖凝集素3 胰岛素样生长因子-1 

分 类 号：R722.1[医药卫生—儿科]