昆仙胶囊相关方案治疗狼疮肾炎的有效性:网状Meta分析  

Efficacy of Kunxian capsule in treating patients with lupus nephritis:A network Meta-analysis

作　　者：李子锋 范玉玲 易文[1] 侯晓强[1] 尹龙[1] 常彩云[1] LI Zifeng;FAN Yuling;YI Wen;HOU Xiaoqiang;YIN Long;CHANG Caiyun(Department of Traditional Chinese Medicine Three Gorges University,the First College of Clinical Medical Science,Yichang Central People's Hospital,Yichang 443000,China)

机构地区：[1]三峡大学第一临床医学院,宜昌市中心人民医院中医科,宜昌443000

出　　处：《中国免疫学杂志》2024年第4期736-740,共5页Chinese Journal of Immunology

摘　　要：目的:系统评价昆仙胶囊相关治疗方案对狼疮肾炎(LN)的有效性,以期为LN患者的治疗策略提供参考依据。方法:计算机检索PubMed、Web of Science、Cochrane Library、CBM、中国知网、万方及维普数据库中昆仙胶囊治疗LN的相关研究,限定时间为数据库建立至2022年4月6日,对符合标准的研究使用R 4.0.2软件与Revman 5.3软件进行Meta分析。结果:最终纳入4个随机对照研究与1个队列研究,包括310例患者。Meta分析结果显示:在24 h尿蛋白与SLEDAI评分方面,糖皮质激素+环磷酰胺+昆仙胶囊治疗后效果最优;在Scr、IgE与IgG方面,糖皮质激素+环磷酰胺+昆仙胶囊各指标水平明显低于糖皮质激素+环磷酰胺,差异有统计学意义(P<0.05)。结论:对比5种方案在治疗LN患者的临床疗效方面,以糖皮质激素+环磷酰胺+昆仙胶囊的效果最佳。因纳入研究的质量与数量限制,还需开展更多高质量的研究进行验证。Objective:To systematically evaluate the effectiveness of Kunxian capsule related regimens for patients with lupus nephritis(LN)in order to provide a reference basis for treatment strategies for LN patients.Methods:The computer searched the relevant studies of Kunxian capsule in PubMed,Web of Science,Cochrane Library,CBM,CNKI,Wanfang and VIP databases on the treatment of LN,the limited time for the establishment of the database is April 6,2022,and used R 4.0.2 software and Revman 5.3 software for Meta-analysis.Results:Four RCTs with 1 cohort study including 310 patients were finally included.The results of the Meta-analysis showed that:In terms of 24 h urinary protein and SLEDAI score,Glucocorticoid+Cyclophosphamide+Kunxian capsule achieved the best result after treatment;in terms of Scr,IgE,and IgG,the levels of each index were significantly lower in Glucocorticoid+Cyclophosphamide+Kunxian capsules than in Glucocorticoid+Cyclophosphamide(P<0.05).Conclusion:The 5 regimens may work best as Glucocorticoids+Cyclophosphamide+Kunxian capsules in terms of clinical efficacy in treating LN patients.Because of the quality and quantity limitations of the included studies,more high-quality studies are needed for validation.

关 键 词：昆仙胶囊 狼疮性肾炎 有效性 META分析 

分 类 号：R593.242[医药卫生—内科学]