SARS-CoV-2 S蛋白主要结构与突变及S蛋白引起疾病的潜在机制  

Min structure and mutation of SARS-CoV-2 S protein and potential mechanism of S protein-induced disease

作　　者：刘兴健 张锐钢 LIU Xingjian;ZHANG Ruigang(Department of Physiology,School of Basic Medicine,Guangdong Medical University,Zhanjiang 524002,China)

机构地区：[1]广东医科大学基础医学院生理学教研室,湛江524002

出　　处：《中国免疫学杂志》2024年第4期857-861,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金(82000008);广东省基础与应用基础研究基金区域联合基金(2019A1515110126)。

摘　　要：严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)对人类生命健康构成威胁,备受研究者的关注。研究发现,病毒的刺突蛋白(S蛋白)被认为是病毒感染的关键结构蛋白,该蛋白与靶细胞受体结合导致组织器官发生炎症反应。因此研究S蛋白引起疾病的潜在机制对于疾病的治疗至关重要,然而病毒的演变进化给研究工作增加了一定的难度。本文总结了SARS-CoV-2 S蛋白的主要结构以及从Alpha到Omicron突变,及其引起多种疾病的潜在机制,从而为疾病的预防和治疗提供参考。SARS-CoV-2 caused severe threat to people's health all over the world,and has attracted widespread attention from researchers.The spike protein of SARS-CoV-2 is a key structure mediating the binding of the virus to its host.Therefore,it is important to elucidate the mechanism of spike protein-induced immune responses.We've reviewed the structure of spike protein from alpha to omicron variant,as well as the potential mechanisms of spike-induced in multiple systems,so as to provide a reference for disease prevention and treatment.

关 键 词：SARS-CoV-2 S蛋白 ACE2 呼吸道炎症 

分 类 号：R332[医药卫生—人体生理学]