拮抗剂方案联合生长激素注射对卵巢低反应患者妊娠结局的影响  

Effect of Antagonist Regimen Combined with Growth Hormone Injection on Pregnancy Outcome in Patients with Ovarian Hyporesponsiveness

作　　者：程婷婷[1] 陈瑜[1] CHEN Tingting;CHEN Yu(Department of Reproductive Medicine,Xuzhou Maternal and Child Health Hospital,Xuzhou,Jiangsu Province,221000 China)

机构地区：[1]徐州市妇幼保健院生殖医学科,江苏徐州221000

出　　处：《中外医疗》2024年第7期31-35,共5页China & Foreign Medical Treatment

摘　　要：目的探讨研究拮抗剂方案联合生长激素(Growth Hormone,GH)注射对卵巢低反应(Ovarian Hypore⁃sponsiveness,POR)患者妊娠结局的影响。方法回顾性选取2020年3月-2023年7月徐州市妇幼保健院进行体外受精-胚胎移植(In Vitro Fertilization-embryo transfer,IVF-ET)治疗并采用拮抗剂方案的80例POR患者的临床资料,根据是否应用GH进行分组,联合GH注射治疗的纳入观察组,单一使用拮抗剂方案的纳入对照组,每组40例。比较两组患者妊娠情况,包括获卵数、第3天可移植胚胎率、囊胚形成率、临床妊娠率、种植率、MⅡ卵率、正常受精率、第3天优质胚胎率和优质囊胚率。结果治疗后,两组MⅡ卵率、正常受精率、第3天优质胚胎率、优质囊胚率比较,差异无统计学意义(P均>0.05)。观察组获卵数为(10.78±4.02)个,高于对照组的(7.36±2.15)个,差异有统计学意义(t=4.745,P<0.05)。观察组在第3天可移植胚胎率、囊胚形成率、临床妊娠率、种植率均高于对照组,差异有统计学意义(P均<0.05)。结论拮抗剂方案联合GH注射可改善POR患者妊娠结局,提高患者生育成功率。Objective To investigate the effect of antagonist regimen combined with growth hormone(GH)injection on pregnancy outcome in patients with ovarian hyporesponsiveness(POR).Methods Clinical data of Eighty patients with POR who underwent in vitro fertilization-embryo transfer(IVF-ET)treatment with antagonist regimen from March 2020 to July 2023 in Xuzhou Maternal and Child Health Hospital were retrospectively selected.They were grouped ac-cording to whether GH was applied or not,those treated with combined GH injection were included in the observation group,and those treated with single antagonist regimen were included in the control group,with 40 cases in both groups.The pregnancy situation of the two groups was compared,including the number of eggs obtained,the rate of transferable embryos on the 3rd day,the rate of blastocyst formation,the clinical pregnancy rate,the implantation rate,the rate of MII eggs,the rate of normal fertilization,the rate of high-quality embryos on the 3rd day and the rate of high-quality blastocysts.Results After treatment,there was no significant difference in MⅡegg rate,normal fertiliza-tion rate,good quality embryo rate and good quality blastocyst rate between the two groups(all P>0.05).The number of eggs collected in observation group(10.78±4.02)was higher than that in control group(7.36±2.15),and the differ-ence was statistically significant(t=4.745,P<0.05).The transplantable embryo rate on the 3rd day,blastocyst forma-tion rate,clinical pregnancy rate and implantation rate in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The antagonist regimen combined with GH injection can improve the pregnancy outcome of POR patients and increase the fertility success rate of the pa-tients.

关 键 词：体外受精-胚胎移植 不孕不育 拮抗剂方案 生长激素 卵巢低反应 妊娠结局 

分 类 号：R711[医药卫生—妇产科学]