乙型肝炎病毒与丙型肝炎病毒合并感染患者的生化免疫结果分析  

Analysis of Biochemical Immune Results in Patients Co-infected with Hepatitis B Virus and Hepatitis C Virus

作　　者：王秀和 WANG Xiuhe(Department of Laboratory,Putian Hanjiang Hospital,Putian,Fujian Province,351100 China)

机构地区：[1]莆田涵江医院检验科,福建莆田351100

出　　处：《中外医疗》2024年第7期48-50,75,共4页China & Foreign Medical Treatment

摘　　要：目的探讨乙型肝炎病毒与丙型肝炎病毒合并感染患者的生化免疫结果。方法回顾性选取2018年10月-2022年10月莆田涵江医院确诊为乙型肝炎病毒和(或)丙型肝炎病毒感染的120例患者的临床资料,其中40例合并感染患者为观察组,40例乙型肝炎病毒感染患者为观察1组,40例丙型肝炎病毒感染患者为观察2组,均进行生化免疫指标检验,观察和记录3组的免疫结果。结果观察组各项免疫学指标相比于观察1组、观察2组更高,差异有统计学意义(P均<0.05)。观察组肝功能指标相比于观察1组更低,相比于观察2组更高,差异有统计学意义(P均<0.05)。观察组凝血酶原时间相比于观察1组、观察2组更高;凝血酶原活动度相比于观察1组、观察2组更低,差异有统计学意义(P均<0.05)。结论乙型肝炎病毒与丙型肝炎病毒合并感染会降低患者的肝脏储备能力,增强炎症反应的发生,加重肝脏的损伤,同时凝血能力增强,可能会促使血栓的形成。Objective To investigate the biochemical and immune results of patients co-infected with hepatitis B virus and hepatitis C virus.Methods The clinical data of 120 patients diagnosed as infection of hepatitis B virus and(or)hepatitis C virus in Putian Hanjiang Hospital from October 2018 to October 2022 were retrospectively selected,of which 40 patients with combined infection were in the observation group,40 patients with hepatitis B virus infection were in the observation group 1,and 40 patients with hepatitis C virus infection were in the observation group 2.The biochemical immune indexes were tested,and the immune results of the 3 groups were observed and recorded.Results The immunological indexes in the observation group were higher than those in the observation group 1 and the obser-vation group 2,and the differences were statistically significant(all P<0.05).The liver function indexes of the observa-tion group were lower than those of the observation group 1,but higher than those of the observation group 2,and the differences were statistically significant(all P<0.05).The prothrombin time in observation group was higher than that in observation group 1 and observation group 2,prothrombin activity was lower than that in observation group 1 and observation group 2,and the differences were statistically significant(all P<0.05).Conclusion Hepatitis B virus and hepatitis C virus co-infected can reduce the liver reserve capacity of patients,enhance the occurrence of inflamma-tion,aggravate liver damage,and enhance the clotting ability,which may promote the formation of thrombus.

关 键 词：乙型肝炎病毒 丙型肝炎病毒 Γ-干扰素 白介素-6 白介素-10 

分 类 号：R512.6[医药卫生—内科学]