依巴斯汀联合吡美莫司乳膏对面部糖皮质激素依赖性皮炎的治疗效果评估分析  

Evaluation of Efficacy of Ebastine Combined with Pimecrolimus Cream in the Treatment of Facial Glucocorticoid-dependent Dermatitis

作　　者：马广 李海英 MA Guang;LI Haiying(Feicheng Hospital of Traditional Chinese Medicine,Feicheng,Shandong Province,271600 China;Feicheng Xincheng Street Community Health Service Center,Feicheng,Shandong Province,271600 China)

机构地区：[1]山东省肥城市中医医院,山东肥城271600 [2]肥城市新城街道社区卫生服务中心,山东肥城271600

出　　处：《中外医疗》2024年第7期117-119,128,共4页China & Foreign Medical Treatment

摘　　要：目的探讨面部糖皮质激素依赖性皮炎应用依巴斯汀联合吡美莫司乳膏治疗的临床效果。方法方便选取2021年1月-2023年6月肥城市中医医院收治的96例面部糖皮质激素依赖性皮炎患者为研究对象,按随机数表法分为对照组和观察组,各48例。对照组单独应用依巴斯汀治疗,观察组在对照组基础上增加吡美莫司乳膏联合治疗。比较两组治疗效果、症状评分和不良反应发生情况。结果观察组治疗总有效率(95.83%)高于对照组(83.33%),差异有统计学意义(χ^(2)=4.018,P<0.05)。观察组治疗后脱屑、色素沉着、皮肤萎缩、丘疹、脓疱、潮红评分均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率和对照组比较,差异无统计学意义(P>0.05)。结论面部糖皮质激素依赖性皮炎使用依巴斯汀联合吡美莫司乳膏治疗,临床治疗效果较好,其各种临床症状均有明显改善,且安全性良好。Objective To investigate the clinical effect of ebastine combined with pimecrolimus cream in the treatment of facial glucocorticoid-dependent dermatitis.Methods A total of 96 patients with glucocorticoid-dependent facial dermatitis admitted to Feicheng Hospital of Traditional Chinese Medicine from January 2021 to June 2023 were conve-niently selected as the research objects and were equally divided into control group and observation group by random number table method,with 48 cases in each group.The control group was treated with ebastine alone,and the observa-tion group was added with pimecrolimus cream on the basis of the control group.The therapeutic effect,symptom score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.83%,higher than that of control group(83.33%),and the difference was sig-nificantly significant(χ^(2)=4.018,P<0.05).After treatment,the scores of descalation,pigmentation,skin atrophy,pap-ule,pustule and flushing in the observation group were lower than those in the control group,and the differences were significantlly significant(all P<0.05).There was no statistically significant difference in the total incidence rate of ad-verse reactions between the observation group and the control group(P>0.05).Conclusion Ebastine combined with pimecrolimus cream used to treat facial glucocorticoid-dependent dermatitis has a high clinical treatment effect,and various clinical symptoms of patients are significantly improved,and the safety is good.

关 键 词：吡美莫司乳膏 面部糖皮质激素依赖性皮炎 依巴斯汀 治疗效果 症状评分 

分 类 号：R5[医药卫生—内科学]