银杏叶提取物注射液联合甲钴胺治疗突发性聋患者的效果  

Effects of Ginkgo biloba extract injection combined with Mecobalamin in treatment of patients with sudden deafness

作　　者：周彩英 李海英 ZHOU Caiying;LI Haiying(Department of Otorhinolaryngology of Renji Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州仁济医院耳鼻喉科,河南郑州450000

出　　处：《中国民康医学》2024年第8期65-67,86,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察银杏叶提取物注射液联合甲钴胺治疗突发性聋患者的效果。方法:选取2021年1月至2022年12月该院收治100例突发性聋患者进行前瞻性研究,按照随机数字法将其分为对照组和观察组各50例。对照组采用甲钴胺注射液治疗,观察组在对照组的基础上采用银杏叶提取物注射液治疗。比较两组临床疗效,症状消失时间,治疗前后血清学指标[可溶性血管细胞黏附分子-1(sVCAM-1)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、降钙素基因相关肽(CGRP)]水平、纯音听阈值,以及不良反应发生率。结果:观察组治疗总有效率为94.00%(47/50),高于对照组的76.00%(38/50),差异有统计学意义(P<0.05);观察组耳聋、耳鸣、眩晕等症状消失时间均短于对照组,治疗后在250、1000、4000 Hz的听阈值均小于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清SOD、CGRP水平高于对照组,sVCAM-1、LPO水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合甲钴胺治疗突发性聋患者效果显著,可加快症状缓解,提高听力水平,改善血清学指标水平,效果优于单用甲钴胺治疗。Objective:To observe effects of Ginkgo biloba extract injection combined with Mecobalamin in treatment of patients with sudden deafness.Methods:A prospective study was conducted on 100 patients with sudden deafness admitted to this hospital from January 2021 to December 2022.According to the random number method,they were divided into control group and observation group,50 cases in each group.The control group was treated with Mecobalamin injection,while the observation group was treated with Ginkgo biloba extract injection on the basis of that of the control group.The clinical efficacy,the symptom disappearance time,the serological indexes[soluble vascular cell adhesion molecule-1(sVCAM-1),lipid peroxide(LPO),superoxide dismutase(SOD),calcitonin gene-related peptide(CGRP)]levels,the pure tone hearing threshold,before and after the treatment and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 76.00%(38/50)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of deafness,tinnitus,vertigo and other symptoms in the observation group were shorter than those in the control group,the hearing thresholds at 250,1000 and 4000 Hz after the treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum SOD and CGRP in the observation group were higher than those in the control group,the levels of sVCAM-1 and LPO were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo biloba extract injection combined with Mecobalamin in the treatment of the patients with sudden deafness has a significant effect,which can accelerate the relief of symptoms,improve the hearing levels and improve the levels of serolo

关 键 词：银杏叶提取物 甲钴胺 突发性聋 氧化应激指标 听力 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]