醋酸曲普瑞林与绒促性素治疗多囊卵巢综合征的效果比较  

Comparison of Efficacy of Triptorelin Acetate and Chorionic Gonadotropin in the Treatment of Polycystic Ovary Syndrome

作　　者：吴芳芳 WU Fangfang(Putian 95 Hospital,Putian 351100,China)

机构地区：[1]莆田九十五医院,福建莆田351100

出　　处：《中外医学研究》2024年第11期54-57,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:比较醋酸曲普瑞林与绒促性素治疗多囊卵巢综合征患者的临床效果。方法:选择2021年1月—2022年12月在莆田九十五医院治疗的102例多囊卵巢综合征患者作为研究对象。根据随机数表法将其分为对照组和观察组,各51例。对照组给予绒促性素治疗,观察组给予醋酸曲普瑞林治疗。比较两组治疗前后的性激素水平[黄体生成素(LH)、雌激素(E2)、卵泡刺激素(FSH)]及排卵质量(优势卵泡数、排卵数),统计并比较两组临床治疗总有效率和不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组排卵数、优势卵泡数、性激素指标水平比较,差异无统计学意义(P>0.05);治疗后,两组排卵数及优势卵泡数均高于治疗前,LH、E_(2)、FSH水平均低于治疗前,且观察组排卵数及优势卵泡数高于对照组,LH、E_(2)、FSH水平低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为5.88%,低于对照组的21.57%,差异有统计学意义(P<0.05)。结论:醋酸曲普瑞林和绒促性素分别治疗多囊卵巢综合征都具备一定效果,但醋酸曲普瑞林效果更理想,可调节患者性激素,改善排卵质量,增强临床效果,安全性较高。Objective:To compare the clinical effects of Triptorelin Acetate and Chorionic Gonadotrophin in the treatment of patients with polycystic ovary syndrome.Method:A total of 102 patients with polycystic ovary syndrome treated in Putian 95 Hospital from January 2021 to December 2022 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 51 cases in each group.The control group was treated with Chorionic Gonadotropin,and the observation group was treated with Triptorelin Acetate.Sex hormone levels[luteinizing hormone(LH),estrogen(E_(2)),folliclestimulating hormone(FSH)]and ovulation mass(number of dominant follicles and number of ovulation)were compared between the two groups before and after treatment,and the total effective rate and incidence of adverse reactions were statistically compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in ovulation number,dominant follicle number and sex hormone index level between the two groups(P>0.05).After treatment,ovulation number and dominant follicle number of both groups were higher than those before treatment,LH,E2 and FSH levels were lower than those before treatment,and ovulation number and dominant follicle number of observation group were higher than those in control group,LH,E2 and FSH levels of observation group were lower than those in control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.88%,which was lower than 21.57%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Triptorelin Acetate and Chorionic Gonadotropin in the treatment of polycystic ovary syndrome respectively have certain effects,but Triptorelin Acetate has better effect,which can regulate sex hormones,improve ov

关 键 词：醋酸曲普瑞林 绒促性素 多囊卵巢综合征 排卵质量 

分 类 号：R711.75[医药卫生—妇产科学]