异烟肼雾化吸入治疗初治菌阳空洞型肺结核的临床研究  

Clinical Study of Atomized Inhalation of Isoniazid in the Treatment of Primary Treatment Germ Positive Cavity-type Pulmonary Tuberculosis

作　　者：李少辉 谢沛栖 覃诗勇 LI Shaohui;XIE Peiqi;QIN Shiyong(Pingnan People's Hospital,Pingnan 537300,China)

机构地区：[1]平南县人民医院,广西平南537300

出　　处：《中外医学研究》2024年第12期64-67,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：贵港市自筹经费科研项目(贵科攻2000011)。

摘　　要：目的:探讨异烟肼雾化吸入治疗初治菌阳空洞型肺结核的效果。方法:选取2021年7月—2022年12月平南县人民医院收治的45例初治菌阳空洞型肺结核患者作为研究对象。根据随机数表法将其分为常规组(n=23)和雾化组(n=22)。常规组给予常规抗结核治疗,雾化组在对照组基础上给予异烟肼雾化吸入治疗。比较两组治疗2个月、6个月后细菌转阴情况,空洞闭合情况及不良反应。结果:雾化组治疗2个月后痰液转阴率高于常规组,平均转阴时间早于对照组,差异有统计学意义(P<0.05)。雾化组治疗2个月、6个月后空洞闭合率均高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异烟肼雾化吸入辅助常规抗结核治疗有更高的痰菌转阴率,痰菌转阴更快,病灶吸收得更好,具有更优的治疗效果,且安全性良好。Objective:To investigate the effect of atomized inhalation of Isoniazid in the treatment of primary treatment germ positive cavity-type pulmonary tuberculosis.Method:Forty-five patients with primary treatment germ positive cavity-type pulmonary tuberculosis admitted to Pingnan People's Hospital from July 2021 to December 2022 were selected as the study objects.They were divided into conventional group(n=23)and atomized group(n=22)according to random number table method.The conventional group was given conventional anti-tuberculosis treatment,and the atomizing group was given Isoniazid atomizing inhalation therapy on the basis of the control group.Bacteria turning negative condition,cavity closure condition after 2 months and 6 months of treatment and adverse reactions were compared between the two groups.Result:After 2 months of treatment,the sputum conversion negative rate of atomization group was higher than that of conventional group,and the average time of sputum conversion negative was earlier than that of control group,the differences were statistically significant(P<0.05).The cavity closure rate after 2 months and 6 months in the atomization group was higher than that in the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Isoniazid nebulization assisted conventional antituberculosis therapy has a higher sputum negative conversion rate,faster sputum negative conversion,better lesion absorption,and better treatment effect with good safety.

关 键 词：异烟肼 雾化吸入 空洞型肺结核 空洞闭合情况 

分 类 号：R521[医药卫生—内科学]