NT与血清β-hCG、PAPP-A、ADAM12单独及联合检测对孕早期DS的诊断价值  

Diagnostic Value of NT and Serumβ-hCG,PAPP-A and ADAM12 Alone and Combination in Detection for DS in Early Pregnancy

作　　者：林琴[1] 肖颜丹 LIN Qin;XIAO Yandan(Xinglin Branch of the First Affiliated Hospital of Xiamen University,Xiamen 361022,China)

机构地区：[1]厦门大学附属第一医院杏林分院,福建厦门361022

出　　处：《中外医学研究》2024年第12期71-74,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨颈部透明层厚度(NT)与血清人绒毛膜促性腺激素(β-hCG)、妊娠相关蛋白A(PAPP-A)及解整合素金属蛋白酶12(ADAM12)单独及联合检测对孕早期唐氏综合征(DS)的诊断价值。方法:选取2019年1月—2023年1月在厦门大学附属第一医院杏林分院经羊膜穿刺确诊的47例DS孕妇作为DS组,另选取同期49例产前检查正常的孕产妇作为对照组,检测并比较两组NT及血清β-hCG、PAPP-A、ADAM12水平,并采用受试者工作特征(ROC)曲线分析NT与血清β-hCG、PAPP-A、ADAM12单独及联合检测对DS的诊断价值。结果:DS组NT及血清β-hCG水平高于对照组,PAPP-A、ADAM12水平均低于对照组,差异有统计学意义(P<0.05)。ROC曲线分析显示,NT与血清β-hCG、PAPP-A、ADAM12联合检测诊断DS的曲线下面积为0.993,预测敏感度、特异度分别为95.7%、98.0%,均高于上述指标单独检测。结论:NT与血清β-hCG、PAPP-A、ADAM12检测对孕早期DS均具有一定的诊断价值,且联合应用诊断效果更高,可作为孕早期DS筛查的有效指标。Objective:To investigate the diagnostic value of cervical hyaline layer thickness(NT)and serum human chorionic gonadotropin(β-hCG),pregnance-related protein A(PAPP-A)and antibody to a disintegrin and metalloprotease 12(ADAM12)alone and combination in detection for Down syndrome(DS)in early pregnancy.Method:A total of 47 pregnant women with DS diagnosed by amniocentesis in Xinglin Branch of the First Affiliated Hospital of Xiamen University from January 2019 to January 2023 were selected as the DS group,and 49 pregnant women with normal prenatal examination during the same period were selected as the control group.NT and serumβ-hCG,PAPP-A and ADAM12 levels were detected and compared between the two groups.The diagnostic value of NT and serumβ-hCG,PAPP-A and ADAM12 in DS was analyzed by receiver operating characteristic(ROC)curve.Result:The levels of NT and serumβ-hCG in DS group were higher than those in control group,and the levels of PAPP-A and ADAM12 were lower than those in control group,the differences were statistically significant(P<0.05).ROC curve analysis showed that the combined detection of NT with serumβ-hCG,PAPP-A and ADAM12 for the diagnosis of DS had an area under the curve of 0.993,and the prediction sensitivity and specificity were 95.7%and 98.0%,respectively,which were higher than the above indexes detected alone.Conclusion:NT and serumβ-hCG,PAPP-A,ADAM12 detection have a certain diagnostic value for DS in early pregnancy,and the combined application has a higher diagnostic effect,and can be used as an effective indicator for DS screening in early pregnancy.

关 键 词：唐氏综合征 孕早期筛查 颈部透明层厚度 血清人绒毛膜促性腺激素 妊娠相关蛋白 解整合素金属蛋白酶12 

分 类 号：R714.5[医药卫生—妇产科学]