急性自发性脑出血患者血清碱性磷酸酶的变化及其临床价值  

Changes and Clinical Value of Serum Alkaline Phosphatase in Patients with Acute Spontaneous Intracerebral Hemorrhage

作　　者：黄文浩 匡文斌 张勇刚 常开源 HUANG Wenhao;KUANG Wenbin;ZHANG Yonggang;CHANG Kaiyuan(Shenzhen Longhua District Central Hospital,Shenzhen 518110,China)

机构地区：[1]深圳市龙华区中心医院,广东深圳518110

出　　处：《中外医学研究》2024年第12期82-85,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:浅析血清碱性磷酸酶(ALP)在急性自发性脑出血中的疾病诊断、病情评估与短期预后评估价值。方法:回顾性分析2019年1月—2020年12月深圳市龙华区中心医院70例因急性自发性脑出血送院抢救患者的临床资料作为观察1组,将同期于本院接受健康体检的70例健康者的临床资料作为对照1组,比较患者治疗前血清ALP水平与健康者的差异,评价其在急性自发性脑出血中的诊断价值。根据观察1组治疗前格拉斯哥昏迷量表(GCS)评分进行分组,GCS<9分为观察2组(n=39),GCS≥9分为对照2组(n=31),对比两组血清ALP水平;观察1组均接受相同方案的治疗,比较治疗前后血清ALP水平,评价其对急性自发性脑出血病情的评估价值。对观察1组进行为期6个月的短期预后随访,统计疾病复发情况,将急性自发性脑出血院外复发者纳入观察3组(n=7),将未复发者纳入对照3组(n=63),对比两组出院前1 d血清ALP水平,评价其对患者短期预后的评估价值。结果:观察1组血清ALP水平高于对照1组,差异有统计学意义(P<0.05);观察2组血清ALP水平高于对照2组,差异有统计学意义(P<0.05);观察1组治疗前血清ALP水平高于治疗后,差异有统计学意义(P<0.05);观察3组出院前1 d血清ALP水平高于对照3组,差异有统计学意义(P<0.05)。结论:血清ALP水平可用于急性自发性脑出血疾病的诊断、病情评估与短期预后评估,是可应用于疾病各阶段的重要指标,能帮助医方更好地识别病情,进而制定后续准确治疗方案。Objective:To analyze the value of serum alkaline phosphatase(ALP)in disease diagnosis,condition evaluation and short-term prognosis evaluation of acute spontaneous intracerebral hemorrhage.Method:The clinical data of 70 patients with acute spontaneous intracerebral hemorrhage admitted to Shenzhen Longhua District Central Hospital from January 2019 to December 2020 were retrospectively analyzed as observation group 1,and 70 healthy people who received physical examination in our hospital during the same period were used as control group 1,the difference of serum ALP level between patients before treatment and healthy people was compared,and its diagnostic value in acute spontaneous intracerebral hemorrhage was evaluated.According to the Glasgow coma scale(GCS)score of the observation group 1 before treatment,the patients with GCS<9 points was divided into the observation group 2(n=39),and the patients with GCS≥9 points was divided into the control group 2(n=31),the serum ALP level between two groups was compared.The observation group 1 was treated with the same regimen,and the serum ALP level before and after treatment was compared to evaluate its value in evaluating the condition of acute spontaneous cerebral hemorrhage.The observation group 1 was followed up for 6 months for short-term prognosis,and the recurrence of the disease was counted.The patients with recurrence of acute spontaneous cerebral hemorrhage outside the hospital were included in the observation group 3(n=7),and the patients without recurrence were included in the control group 3(n=63).The serum ALP level at 1 d before discharge was compared between two groups to evaluate its value in evaluating the short-term prognosis of patients.Result:The serum ALP level of the observation group 1 was higher than that of the control group 1,and the difference was statistically significant(P<0.05).The serum ALP level of the observation group 2 was higher than that of the control group 2,and the difference was statistically significant(P<0.05).The serum ALP

关 键 词：急性自发性脑出血 血清碱性磷酸酶 诊断 病情 预后 评估 

分 类 号：R743.34[医药卫生—神经病学与精神病学]