自拟中药方剂联合阿奇霉素序贯治疗小儿支原体肺炎的临床效果  

Clinical efficacy of self-made traditional Chinese medicine formula combined with azithromycin sequential therapy in children with mycoplasma pneumonia

作　　者：张亚文 ZHANG Ya-wen(Nanping First Hospital,Nanping 353000,China)

机构地区：[1]南平市第一医院,353000

出　　处：《中国现代药物应用》2024年第8期126-129,共4页Chinese Journal of Modern Drug Application

摘　　要：目的观察自拟中药方剂联合阿奇霉素序贯治疗小儿支原体肺炎的临床效果。方法60例小儿支原体肺炎患儿,以随机数字表法分成对照组和研究组,各30例。对照组以阿奇霉素序贯治疗,研究组在对照组基础上联合自拟中药方剂治疗。比较两组患儿治疗前后的血清炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)]水平,咳嗽咳痰、发热、湿啰音、哮鸣音显著改善与消失时间,治疗效果,不良反应发生情况。结果研究组治疗前的CRP、PCT、IL-6水平分别为(30.96±2.76)mg/L、(2.95±0.27)ng/ml、(69.75±1.52)pg/ml,治疗后的CRP、PCT、IL-6水平分别为(13.86±2.22)mg/L、(0.69±0.11)ng/ml、(24.49±1.45)pg/ml;对照组治疗前的CRP、PCT、IL-6水平分别为(30.71±2.88)mg/L、(2.83±0.24)ng/ml、(70.01±1.47)pg/ml,治疗后的CRP、PCT、IL-6水平分别为(17.17±3.55)mg/L、(0.98±0.18)ng/ml、(37.18±2.31)pg/ml。治疗后,两组CRP、PCT、IL-6水平较治疗前下降,其中研究组下降更多(P<0.05)。研究组患儿咳嗽咳痰、发热、湿啰音、哮鸣音显著改善时间分别为(2.25±0.25)、(1.88±0.57)、(2.53±0.27)、(2.88±0.57)d,消失时间分别为(3.14±0.23)、(2.75±0.52)、(5.65±0.97)、(5.35±0.79)d;对照组患儿咳嗽咳痰、发热、湿啰音、哮鸣音显著改善时间分别为(3.34±0.45)、(2.65±0.66)、(3.96±0.18)、(4.24±0.93)d,消失时间分别为(4.76±0.61)、(4.08±0.76)、(6.91±1.16)、(6.94±1.53)d。研究组患儿咳嗽咳痰、发热、湿啰音、哮鸣音显著改善与消失时间与对照组相比更短(P<0.05)。研究组患儿治疗总有效率93.33%高于对照组的70.00%,且不良反应发生率3.33%低于对照组的26.67%(P<0.05)。结论相对于阿奇霉素持续治疗,序贯治疗可以更好地控制病情、缩短病程,而配合使用自拟中药方剂,在缩短病程,减少不良反应发生的效果上更为理想。Objective To observe the clinical efficacy of self-made traditional Chinese medicine formula combined with azithromycin sequential therapy in children with mycoplasma pneumonia.Methods 60 child patients with mycoplasma pneumonia were divided into a control group and a study group using a random number table method,with 30 cases in each group.The control group was treated with azithromycin sequential therapy,while the study group was treated with self-made traditional Chinese medicine formula based on the control group.Comparison was made on the levels of serum inflammatory markers[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)]before and after treatment,improvement time and disappearance time of cough and sputum,fever,moist rale and wheezing rale,therapeutic effect,and occurrence of adverse reactions between two groups of children.Results In the study group,the levels of CRP,PCT,and IL-6 before treatment were(30.96±2.76)mg/L,(2.95±0.27)ng/ml,and(69.75±1.52)pg/ml,respectively.After treatment,the levels of CRP,PCT,and IL-6 were(13.86±2.22)mg/L,(0.69±0.11)ng/ml,and(24.49±1.45)pg/ml,respectively.In the control group,the levels of CRP,PCT,and IL-6 before treatment were(30.71±2.88)mg/L,(2.83±0.24)ng/ml,and(70.01±1.47)pg/ml,respectively.After treatment,the levels of CRP,PCT,and IL-6 were(17.17±3.55)mg/L,(0.98±0.18)ng/ml,and(37.18±2.31)pg/ml,respectively.After treatment,CRP,PCT,and IL-6 levels decreased in both groups compared with those before treatment,with a greater decrease in the study group(P<0.05).In the study group,the time of significant improvement of cough and sputum,fever,moist rale and wheezing rale were(2.25±0.25),(1.88±0.57),(2.53±0.27)and(2.88±0.57)d;the disappearance time were(3.14±0.23),(2.75±0.52),(5.65±0.97)and(5.35±0.79)d.In the control group,the significant improvement time of cough,sputum production,fever,moist rale and wheezing rale were(3.34±0.45),(2.65±0.66),(3.96±0.18)and(4.24±0.93)d;the disappearance time were(4.76±0.61),(4.08±0.76),(6.91±1.16)and(6.9

关 键 词：自拟中药方剂 阿奇霉素 序贯治疗 小儿支原体肺炎 血清炎性指标 

分 类 号：R725.6[医药卫生—儿科]