重复经颅磁刺激联合小儿智力糖浆治疗孤独症患儿的临床效果  

Effects of Repeated Transcranial Magnetic Stimulation Combined with Pediatric Syrup on Attention Span and Neurotrophic Factors in Children with Autism

作　　者：李音凡 LI Yin-fan(Department of Pediatric Rehabilitation,General Hospital of Jinshui District of Zhengzhou City,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院儿童康复科,郑州450000

出　　处：《实用临床医学（江西）》2024年第2期50-53,共4页Practical Clinical Medicine

摘　　要：目的探讨重复经颅磁刺激(rTMS)联合小儿智力糖浆治疗对孤独症患儿注意力、神经营养因子的影响。方法将86例孤独症患儿按不同治疗方案分为对照组(n=43)与观察组(n=43)。2组均予常规综合康复训练,在此基础上对照组予小儿智力糖浆治疗,观察组予rTMS联合小儿智力糖浆治疗,2组均持续治疗6个月。比较2组治疗前、治疗6个月后病情严重程度[采用孤独症治疗评定量表(ATEC)、孤独症行为评定量表(ABC)进行评价,其中ATEC评分从社交、语言交流、知觉、健康行为4个维度分别进行评价]、综合注意力[采用视听整合的持续性操作测验(IVA-CPT)软件检测、计算综合注意力商数]、血清脑源性神经营养因子(BDNF)水平的变化。结果2组治疗后ATEC量表的社交、语言交流、知觉、健康行为评分及ABC评分均较治疗前显著降低,注意力商数均较治疗前显著增加,且观察组治疗后改善程度较对照组更为显著,差异均有统计学意义(P<0.05)。观察组治疗后血清BDNF水平显著高于治疗前及对照组治疗后(P<0.05),对照组治疗前后血清BDNF水平比较差异无统计学意义(P>0.05)。结论重复经颅磁刺激联合小儿智力糖浆治疗相较于单用小儿智力糖浆治疗对促进患儿脑内神经元生长、发育,集中患儿综合注意力,改善患儿核心症状、病情程度等效果更具优势,利于患儿正常生长发育。Objective To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)combined with pediatric syrup on attention span and neurotrophic factors in children with autism.Methods 86 children with autism were divided into the control group(n=43)and the observation group(n=43)according to different treatment plans.On the basis of routine comprehensive rehabilitation training treatment for both groups,the children in the control group were further treated with pediatric syrup,whereas the observation group were treated with rTMS combined with pediatric syrup.Both groups were treated for 6 months.Autism Treatment Evaluation Checklist(ATEC)and Autism behavior checklist(ABC)scores(evaluated from 4 dimensions,namely,social,verbal communication,perceptual,and health behaviors,respectively),comprehensive attention[detected using the audio-visual Integrated Continuous Processing Test(IVA-CPT)software,and computed comprehensive attention quotient],and serum brain-derived neurotrophic factor(BDNF)levels were compared between the two groups before treatment and 6 months after treatment.Results The ATEC and ABC scores of the 2 groups in social,verbal communication,perceptual,and health behavior dimensions were significantly lower after treatment than those before treatment;the attention quotient was significantly higher after treatment than those before treatment;the improvement of the observation group was more significant than that of the control group,and the differences were all statistically significant(P<0.05).The level of BDNF in the Observation Group after treatment was significantly higher than that before treatment and that in the control group after treatment(P<0.05).There was no significant difference in the level of BDNF in the control group before and after treatment(P>0.05).Conclusion rTMS combined with pediatric syrup might be more advantageous than pediatric syrup treatment alone in promoting the growth and development of neurons in the brain of autistic children,improving comprehensive attentio

关 键 词：重复经颅磁刺激 小儿智力糖浆 孤独症 注意力 神经营养因子 

分 类 号：R729[医药卫生—儿科]