结合病例谈乙二胺四乙酸二钾依赖性假性血小板减少的机制  

Case Discussion of Mechanism for Ethylenediaminetetraacetic Acid Dipotassium Salt Dihydrate-Dependent Pseu⁃dothrombocytopenia

作　　者：李文静[1] 马森 梁万蒙 Li Wenjing;Ma Sen;Liang Wanmeng(Department of Clinical Laboratory,Community Health Service Center,Capital Normal University,Beijing 100048,China;Department of Clinical Laboratory,Beijing Fengtai Youanmen Hospital,Beijing 100071,China)

机构地区：[1]首都师范大学社区卫生服务中心检验科,北京100048 [2]北京市丰台区右安门医院检验科,北京100071

出　　处：《中国社区医师》2024年第9期128-130,共3页Chinese Community Doctors

摘　　要：目的:分析乙二胺四乙酸二钾(EDTA-K_(2))依赖性假性血小板减少症(EDTA-PTCP)的机制。方法:回顾性分析1例EDTA-PTCP病例,探讨EDTA-PTCP的机制及纠正措施。结果:EDTA-K_(2)抗凝静脉血测定的16次具体数据随时间变化呈下降趋势。测定结果在5 min后开始下降,10~20 min偏差在允许范围内,25 min及以后偏差超出行业要求,至2 h时下降明显。结论:工作人员应熟悉血小板水平下降的常见原因,在EDTA-PTCP的发生与患者临床表现不符时引起足够重视。在实际工作中,应逐步完善针对假性血小板减少的防范措施,注重临床沟通,及时纠正检验结果,为临床提供更加精准的检验数据。Objective:To analyze the mechanism of ethylenediaminetetraacetic acid dipotassium salt dihydrate(EDTA-K_(2))-dependent pseudothrombocytopenia(EDTA-PTCP).Methods:A retrospective analysis was performed for one case with EDTA-PTCP,andtheEDTA-PTCP mechanism and corrective measures were discussed.Results:Thespecific data of 16EDTA-K_(2) anticoagulant venous blood assays showed a downward trend with time.The assay results began to decline after 5 min,the deviation during 10-20 min was within the allowable range,the deviation at and after 25 min exceeded the industry requirements,and a significant decline was present at 2 h.Conclusion:Laboratory personnel should be well-acquainted with the common causes of platelet decrease and remain vigilant when clinical manifestations of patients do not correspond with the occurrence of EDTA-PTCP.Practically,enhancing preventive strategies against pseudothrombocytopenia,improving clinical communication,and timely correction of test results are essential to providing more precise laboratory data for clinical practice.

关 键 词：血小板聚集 乙二胺四乙酸二钾 假性血小板减少 

分 类 号：R446.11[医药卫生—诊断学]