基于胆碱类低共熔溶剂高效提取香附总黄酮的研究  

Study on High Efficiency Extraction of Total Flavonoids of Rhizoma Fragrans Based on Choline Low Eutectic Solven

作　　者：赵晓娟[1] 胡律江[1] 郭晓秋[1] 郭慧玲[2] ZHAO Xiao-juan;HU Lv-jiang;GUO Xiao-qiu;GUO Hui-ling(Department of Pharmacy,Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)

机构地区：[1]江西中医药大学附属医院药学部 [2]江西中医药大学药学院,江西南昌330006

出　　处：《宜春学院学报》2024年第3期1-3,12,共4页Journal of Yichun University

基　　金：国家自然科学基金项目(编号:82160737);江西省中医药管理局科技计划项目(编号:2020Z005)。

摘　　要：目的:采用胆碱类低共熔溶剂高效提取香附药效组分总黄酮。方法:通过中心组合设计法,对胆碱类低共熔溶剂的性质(种类、组分摩尔比、含水量)、提取温度、提取时间、液料比等因素进行分析。结果:研究发现,香附总黄酮的最佳提取条件为:以氯化胆碱为氢键供体,以丙三醇为氢键受体,摩尔比1∶2,含水量20%,配比1∶4,水比例30%,提取温度80℃,提取时间40 min,液固比为15 mL/g。结论:本研究提示可将胆碱类低共熔溶剂作为可持续、高效的天然提取介质应用于香附药效组分的提取。Objective:To extract the total flavonoids of Rhizoma fragrans by choline-low eutectic solvent.Methods:The nature of choline based low eutectic solvents(type,molar ratio of components,water content),extraction temperature,extraction time,liquid to material ratio and other factors were analyzed by the central combination design method.Results:It was found that the optimum extraction conditions for the total flavonoids of Cyperus Rotundus were:taking choline chloride as the hydrogen bond donor,propanetriol as the hydrogen bond acceptor,molar ratio 1∶2,20%water content,ratio 1∶4,30%water,extraction temperature 80℃,extraction time 40min,liquid-solid ratio 15mL/g.Conclusion:The present study suggests that choline-based low eutectic solvents can be applied as sustainable and efficient natural extraction media for the extraction of the pharmacodynamic components of Cyperus Rotundus.

关 键 词：胆碱类低共熔溶剂 香附总黄酮 中心组合设计 

分 类 号：R94[医药卫生—药剂学]