基于NF-κB信号通路探讨乌梅丸联合消痔灵治疗慢性放射性直肠炎作用机制  

Study on the Mechanism of Action of Mume Pill Combined with Xiaozhiling in the Treatment of Chronic Radiation Proctitis Based on NF⁃κB Signaling Pathway

作　　者：马玉婷 杜燕红 杨德群[1,2] MA Yuting;DU Yanhong;YANG Dequn(Hubei University of Chinese Medicine,Wuhan,Hubei,China,430000;Hubei Provincial Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine Affiliated to Hubei University of Chinese Medicine,Wuhan,Hubei,China,430000)

机构地区：[1]湖北中医药大学,湖北武汉430000 [2]湖北中医药大学附属湖北省中医院,湖北武汉430000

出　　处：《河南中医》2024年第5期784-789,共6页Henan Traditional Chinese Medicine

基　　金：湖北省中医药管理局2023—2024年度中医药指导性项目(ZY2023F001)。

摘　　要：乌梅丸治疗慢性放射性直肠炎可能通过抑制核转录因子-κB(nuclear factor kappa-B,NF-κB)信号通路转导的上游调控点IκB激酶(IκB kinase,IKK),下调IκB蛋白磷酸化,进而抑制NF-κB活化,还可通过下调免疫性结肠炎结肠NF-κB表达,抑制白细胞介素(interleukin,IL)-1β的产生,减轻炎性反应;消痔灵灌肠治疗放射性直肠炎,可以有效降低炎性因子水平,提高临床疗效。乌梅丸联合消痔灵可以通过NF-κB抑制肠道炎性反应,对慢性放射性直肠炎有一定的疗效。但目前,国际与国内关于慢性放射性直肠炎的研究较少,分子结构尚不明确,诊断与治疗缺乏统一性,且乌梅丸组成众多,各方药具有多种药理作用,研究机制较为复杂。今后,需开展动物实验及循证医学研究,以进一步验证消痔灵联合乌梅丸治疗慢性放射性直肠炎的作用机制。Mume Pill in the treatment of chronic radiation proctitis may inhibit the upstream regulatory point of nuclear factor kappa⁃B(NF⁃κB)signaling pathway transduction,down⁃regulate the phosphorylation of IκB protein,and then inhibit the activation of NF⁃κB.It can also down⁃regulate the expression of NF⁃κB in colon of immune colitis,inhibit the production of interleukin(IL)⁃1β,and reduce inflammatory response.Xiaozhiling(消痔灵,XZL)for enema in the treatment of radiation proctitis can effectively reduce the level of inflammatory factors and improve clinical efficacy.Mume Pill combined with XZL has a certain effect on chronic radiation proctitis by inhibiting intestinal inflammatory response through NF⁃κB.However,at present,there are few studies on chronic radiation proctitis at home and abroad,the molecular structure is not clear,and the diagnosis and treatment lack unity.Moreover,Mume Pill has many compo⁃nents,and each drug has a variety of pharmacological effects,and the research mechanism is complex.In the future,animal experiments and evidence⁃based medicine research are needed to further verify the mechanism of action of XZL combined with Mume Pill in the treatment of chronic radiation proctitis.

关 键 词：乌梅丸 消痔灵 慢性放射性肠炎 NF-ΚB信号通路 《伤寒论》 张仲景 

分 类 号：R259.746.3[医药卫生—中西医结合]