慢性非缺血性心力衰竭患者血小板PAC-1和CD62p的表达及其与心功能的关系  

Expression of PAC-1 and CD62p in patients with chronic non-ischemic heart failure and their relationships with cardiac function

作　　者：马丽娜 曹振华[2] 杨冰 MA Li-na;CAO Zhen-hua;YANG Bing(Department of Health Management,Tianjin Hospital,Tianjin 300211,CHINA;Department of Cardiology,Tianjin Nankai Hospital,Tianjin 300100,CHINA;Department of Cell Biology,Tianjin Medical University,Tianjin 300070,CHINA)

机构地区：[1]天津市天津医院健康管理科,天津300211 [2]天津市南开医院心血管内科,天津300100 [3]天津医科大学细胞生物学系,天津300070

出　　处：《海南医学》2024年第9期1298-1302,共5页Hainan Medical Journal

摘　　要：目的探讨慢性非缺血性心力衰竭患者血小板膜糖蛋白纤维蛋白原受体(PAC-1)和P选择素(CD62p)的表达及其与心功能的关系。方法选取2019年1月至2022年1月天津市南开医院收治的185例慢性非缺血性心力衰竭患者作为观察组,根据纽约心脏病学会(NYHA)心功能分级将观察组患者分为心功能Ⅱ级组58例、心功能Ⅲ级组88例和心功能Ⅳ级组39例,根据左室射血分数(LVEF)将观察组患者分为射血分数保留心衰组(HFpEF)123例、射血分数临界值心衰组(HFmrEF)25例和射血分数下降心衰组(HFrEF)37例,再以B型钠尿肽(BNP)中位数为界将观察组患者分为高BNP组109例和低BNP组76例;另选取同期心功能正常的就诊者55例作为对照组。比较各组患者的基本临床信息、生化、BNP指标和PAC-1、CD62p的表达水平,采用Pearson相关分析法分析PAC-1、CD62p水平与BNP、LVEF的关系。结果观察组患者的PAC-1、CD62p水平分别为(23.67±16.54)%、(10.43±9.19)%,明显高于对照组的(9.33±9.63)%、(4.24±5.49)%,差异均有统计学意义(P<0.05);不同心功能分级患者对比发现,PAC-1、BNP水平为Ⅳ级>Ⅲ级>Ⅱ级>对照组,CD62p水平为Ⅳ级>Ⅲ级、Ⅱ级>对照组,差异均有统计学意义(P<0.05);不同LVEF分级患者对比发现,PAC-1水平为HFrEF组>HFmrEF组、HFpEF组>对照组,BNP水平为HFrEF组>HFmrEF组>HFpEF组>对照组,HFpEF组、HFmrEF组、HFrEF组CD62p水平分别为(10.72±9.17)%、(9.87±11.19)%、(9.84±7.88)%,明显高于对照组的(4.24±5.49)%,差异均有统计学意义(P<0.05);高BNP组患者的PAC-1、CD62p分别为(26.97±16.94)%、(11.05±9.62)%,明显高于低BNP组的(13.80±12.82)%、(6.97±7.54)%,差异均有统计学意义(P<0.05);经Pearson相关分析结果显示,PAC-1、CD62p与BNP呈正相关(r=0.363、0.182,P<0.05),PAC-1与LVEF呈负相关(r=-0.297,P<0.05)。结论慢性非缺血性心力衰竭患者的PAC-1、CD62p水平均明显增高,且与心功能有关,检测其水平有助于为患者的病情Objective To investigate the expression levels of platelet membrane glycoprotein fibrinogen receptor(PAC-1)and P-selection(CD62p)in patients with chronic non-ischemic heart failure and their relationships with cardiac function.Methods A total of 185 patients with chronic non-ischemic heart failure admitted to Tianjin Nankai Hospital from January 2019 to January 2022 were selected as the observation group.The patients of observation group were divided into gradeⅡ(58 cases),gradeⅢ(88 cases),and gradeⅣcardiac function group(39 cases)according to cardiac function grading of New York Heart Association(NYHA).According to left ventricular ejection fraction(LVEF),the patients of observation group were divided into heart failure with preserved ejection fraction(HFpEF,123 cases),midrange ejection fraction(HFmrEF,25 cases),and reduced ejection fraction group(HFrEF,37 cases).And according to the median of B-type natriuretic peptide(BNP),the patients of observation group were divided into high BNP group(109 cases)and low BNP group(76 cases).Another 55 subjects with normal cardiac function were enrolled as the control group.Basic clinical information,biochemical indicators,BNP,and PAC-1,CD62p levels were compared among patients of each group.The relationship of PAC-1,CD62p levels with BNP,LVEF was analyzed by Pearson correlation analysis.Results The levels of PAC-1 and CD62p in patients of the observation group were(23.67±16.54)%and(10.43±9.19)%,respectively,significantly higher than(9.33±9.63)%and(4.24±5.49)%of the control group(P<0.05).Comparison on the levels of PAC1 and BNP among patients with different cardiac function grades were manifested as gradeⅣ>gradeⅢ>gradeⅡ>control group,and CD62p was shown as gradeⅣ>gradeⅢ,gradeⅡ>control group,with statistically significant differences(P<0.05).Comparison on the level of PAC1 among patients with different LVEF grades were manifested as HFrEF group>HFmrEF,HFpEF group>control group,and BNP was shown as HFrEF group>HFmrEF group>HFpEF group>control group.The leve

关 键 词：非缺血性心衰 慢性心力衰竭 血小板膜糖蛋白纤维蛋白原受体 P选择素 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]