肺通气功能联合血液学指标对支气管肺炎患儿预后的预测价值  

Predictive value of pulmonary ventilation function combined with hematological indicators for the prognosis of children with Mycoplasma pneumoniae pneumonia

作　　者：康芳芳 薛涛 李吊如 KANG Fang-fang;XUE Tao;LI Diao-ru(Children's Respiratory and Digestive Department,Yulin Children's Hospital,Yulin 719000,Shaanxi,CHINA)

机构地区：[1]榆林市儿童医院儿童呼吸消化科,陕西榆林719000

出　　处：《海南医学》2024年第9期1303-1306,共4页Hainan Medical Journal

摘　　要：目的探讨肺通气功能检查联合中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)等指标对支原体肺炎(MPP)患儿预后的预测价值。方法回顾性选取2021年1月至2023年12月榆林市儿童医院收治的50例预后良好MPP患儿作为预后良好组,选取同一个时间段的55例预后不良MPP患儿作为预后不良组。比较两组患儿入院后第2天的肺功能相关指标、NLR、PLR指标以及临床肺部感染评分(CPIS)评分。应用多因素Logistic回归分析影响MPP患儿预后影响因素,绘制受试者工作特征曲线(ROC)分析肺功能相关指标、NLR、PLR指标以及CPIS评分对患儿预后的预测价值。结果预后良好组患儿的用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC分别为(2.1±0.6)L、1.5±0.4、(54.2±5.6)%,明显低于预后不良组的(3.7±0.9)L、2.6±0.8、(72.2±7.3)%;而NLR、PLR水平和CPIS评分分别为2.6±0.8、158.1±46.1、(6.9±1.2)分,明显高于预后不良组的1.9±0.5、126.9±32.5、(4.2±0.8)分,差异均有统计学意义(P<0.05);经多因素Logistic回归分析结果显示,肺功能指标、NLR、PLR及CPIS评分均是MPP患儿预后的独立影响因素(P<0.05);经ROC分析结果显示,肺功能指标、血液标志物及CPIS评分单独及联合预测MPP患儿预后不良的AUC分别为0.612、0.690、0.710、0.793、0.736、0.634及0.913,各指标联合效能高于各项单独检测(P<0.05)。结论肺功能指标、NLR、PLR及CPIS评分联合检测在预测MPP患儿预后方面具有一定的预测价值,可作为检测指标指导其临床治疗。Objective To explore the prognostic value of pulmonary ventilation function combined with neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)for the prognosis of children with Mycoplasma pneumoniae pneumonia(MPP).Methods A total of 50 children with MPP admitted into Yulin Children's Hospital from January 2021 to December 2023 were selected as good prognosis group,and fifty-five children with MPP at the same time were selected as the poor prognosis group.Pulmonary function,NLR,PLR,and clinical pulmonary infection score(CPIS)were compared between the two groups on the second day after admission.Multivariate Logistic regression analysis was used to analyze the prognostic factors of children with MPP,and the receiver operating characteristic(ROC)curve was drawn to analyze the prognostic value of lung function,NLR,PLR,and CPIS score.Results The forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and FEV1/FVC in the good prognosis group were(2.1±0.6)L,1.5±0.4,(54.2±5.6)%,which were significantly lower than(3.7±0.9)L,2.6±0.8,(72.2±7.3)%in the poor prognosis group;The NLR,PLR,and CPIs scores were 2.6±0.8,158.1±46.1,(6.9±1.2)points,which were significantly higher than 1.9±0.5,126.9±32.5,(4.2±0.8)points in the poor prognosis group;the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that lung function index,NLR,PLR,and CPIs score were independent prognostic factors for MPP children(P<0.05).ROC analysis showed that the AUC of lung function indicators,blood markers,and CPIs score alone and in combination to predict the poor prognosis of children with MPP were 0.612,0.690,0.710,0.793,0.736,0.634,and 0.913,respectively.The efficacy of combined detection was significantly higher than that of each individual detection(P<0.05).Conclusion The combined detection of lung function index,NLR,PLR,and CPIs score has a certain predictive value in predicting the prognosis of children with MPP,and these indicators can be used as a detect

关 键 词：支原体肺炎 肺通气功能 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 病情进展 预后 预测价值 

分 类 号：R725.6[医药卫生—儿科]