不同产地连翘质量的研究现状分析  

Analysis of the quality research progress of Forsythiae fructus from different producing areas

作　　者：杨允 王园 王晓婷 王春柳[2] 刘洋[2] 孙婷婷[2] 房敏峰[1] 龙凯花 张红[2] YANG Yun;WANG Yuan;WANG Xiaoting;WANG Chunliu;LIU Yang;SUN Tingting;FANG Minfeng;LONG Kaihua;ZHANG Hong(School of Life Science,Northwest University,Xi’an 710069,China;Shaanxi Academy of Traditional Chinese Medicine,Xi’an 710003,China)

机构地区：[1]西北大学生命科学学院,西安710069 [2]陕西省中医药研究院,西安710003

出　　处：《西北药学杂志》2024年第3期1-9,共9页Northwest Pharmaceutical Journal

基　　金：陕西省重点研发计划项目(编号:2022ZDXM-SF-06,2024SF-YBXM-489);西安市科技计划项目(编号:23YXYJ0142);陕西省科协青年人才托举计划项目(编号:20230321);秦创原中医药创新研发转化项目(编号:2022-QCYZH-006);“秦药”研发重点实验室项目(编号:2021-QYPT-001);“秦药”质量提升工程项目(编号:2021-QYZL-01);陕西省中医药研究院“苗圃培育计划”项目(编号:2021-15)。

摘　　要：目的总结不同产地连翘质量控制的研究现状。方法通过收集连翘中主要化学成分的研究文献资料,对不同产地连翘中主要化学成分(总挥发油、连翘酯苷A、连翘酯苷B、连翘苷和微量元素钠、锰、锌、铁、镁、钾、钙、铬、锗、硒及重金属铅、镉、砷、汞、铜)的含量研究结果进行数据收集和比较。结果由统计分析结果可知,陕西、湖北、安徽的样本挥发油质量分数均值约为1.7%,为最高;河南、陕西和山西的连翘酯苷A含量排名靠前,分别为5.47%、4.90%、4.83%;山西连翘中的连翘酯苷B样本量最高且含量均值高于其他产地;山西连翘微量元素优势较大,山西运城、太原、临汾、晋中产地的连翘中的Mn、Fe、Mg、K、Ca、Cr、Ge、Se质量分数居于前列,Na、Zn分别是河南三门峡、河北邯郸产地较优;各产地连翘的重金属含量均未超标。结论山西、河南、陕西、河北作为连翘的主要产区,多种化学成分的质量分数普遍高于其他产区,品质更为优良。本文为开展不同产地连翘的共性和个性特征研究提供了数据支撑,为各产地连翘的质量控制提供了参考。Objective To summarize the current research status of Forsythiae fructus constituents from different producing areas.Methods By collecting research literature on the main chemical components of F.fructus from different regions,data collection and comparison were conducted on the content of the main chemical components total volatile oil,forsythia glycoside A,forsythia glycoside B,forsythin,trace elements sodium(Na),manganese(Mn),zinc(Zn),iron(Fe),magnesium(Mg),potassium(K),calcium(Ca),chromium(Cr),germanium(Ge),selenium(Se),and heavy metals such as lead(Pb),cadmium(Cd),arsenic(As),mercury(Hg),copper(Cu)in F.fructus from different regions.Results From the statistical analysis results,the average mass-fraction of volatile oil in samples from Shaanxi,Hubei,and Anhui was about 1.7%,higher than that from other areas.The contents of forsythia glycoside A in samples from He’nan,Shaanxi,and Shanxi were 5.47%,4.90%,and 4.83%,respectively.The contents of forsythia glycoside B in samples from Shanxi F.fructus was the highest.F.fructus from Shanxi has a significant advantage in trace elements.The mass-fractions of Mn,Fe,Mg,K,Ca,Cr,Ge,and Se in the samples from Yuncheng,Taiyuan,Linfen,and Jinzhong of Shanxi were higher than from other areas,while Na and Zn in the samples from Sanmenxia of He’nan and Handan of Hebei were higher than that from other areas.The heavy metal content of F.fructus did not exceed the standard in all producing areas.Conclusion Shanxi,He’nan,Shaanxi,and Hebei,as the main production areas of F.fructus,generally have higher mass-fractions of various chemical constituents than other production areas,resulting in better quality.This article provides data support for conducting research on the common and individual characteristics of F.fructus from different producing areas,and provides reference for the quality control of F.fructus from different producing areas.

关 键 词：连翘 挥发油 连翘酯苷A 连翘苷 微量元素 重金属 

分 类 号：R284.1[医药卫生—中药学]