湿润烧伤膏联合光子治疗仪对糖尿病足溃疡愈合的影响  

Effects of Moist Exposed Burn Ointment combined with photon therapeutic apparatus on healing of diabetic foot ulcer

作　　者：邢少云 冯俊花 XING Shaoyun;FENG Junhua(Department of Skin Rehabilitation,Hainan Fifth People’s Hospital,Haikou 570311,China)

机构地区：[1]海南省第五人民医院皮肤康复科,海口570311

出　　处：《西北药学杂志》2024年第3期95-99,共5页Northwest Pharmaceutical Journal

基　　金：海南省医药卫生科研项目(编号:15032071A2001)。

摘　　要：目的考察湿润烧伤膏(Moist Exposed Burn Ointment,MEBO)联合光子治疗仪对糖尿病足(diabetic foot,DF)溃疡患者创面愈合及对血清碱性成纤维细胞生长因子(basic fibrblast growth factor,bFGF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)及转化生长因子β_(1)(transforming growth factor-β_(1),TGF-β_(1))水平的影响。方法选取接受治疗的110例DF溃疡患者作为研究对象,根据治疗方法不同分为联合治疗组(n=54)和光子治疗仪组(n=56)。光子治疗仪组用光子治疗仪治疗,联合治疗组应用MEBO联合光子治疗仪治疗,比较2组患者创面愈合情况[创面愈合时间、创面缩小面积和创面愈合率]、创面氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、晚期蛋白氧化产物(advanced oxidation protein products,AOPP)]、创面渗液指标[血清基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)、蛋白Samd-3(sterile alpha motif domaincontaining protein 3,Samd-3)和金属蛋白酶组织抑制剂-2(tissue inhibitor of metalloproteinase-2,TIMP-2)]和bFGF、VEGF和TGF-β_(1)水平及不良反应发生率情况。结果治疗后,联合治疗组创面愈合时间短于光子治疗仪组,创面缩小面积大于光子治疗仪组,创面愈合率高于光子治疗仪组(P<0.05)。治疗后,2组SOD水平均有所升高,且联合治疗组高于光子治疗仪组(P<0.05),2组AOPP、MDA水平均有所下降,且联合治疗组低于光子治疗仪组(P<0.05)。2组MMP-2、Samd-3水平均有所降低,联合治疗组低于光子治疗仪组(P<0.05),2组TIMP-2有所上升,且联合治疗组高于光子治疗仪组(P<0.05)。2组血清指标TGF-β_(1)、VEGF和bFGF均有所升高,联合治疗组高于光子治疗仪组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论湿润烧伤膏能够降低氧化应激水平,抑制炎症反应,提高血清bFGF、TGF-β_(1)水平,缩短创面愈合时间,加速创面愈合速度。Objective To explore the effects of Moist Exposed Burn Ointment(MEBO)combined with photon therapeutic apparatus on wound healing,serum basic fibroblast growth factor(bFGF),vascular endothelial growth factor(VEGF)and transforming growth factorβ_(1)(TGF-β_(1))in patients with diabetic foot(DF)ulcer.Methods A total of 110 patients with DF ulcer were enrolled as the research objects.According to different treatment methods,they were divided into combined treatment group(n=54)and photon therapeutic apparatus group(n=56).The photon therapeutic apparatus group was treated with photon therapeutic apparatus,while the combined treatment group was additionally treated with MEBO.The wound healing(wound healing time,wound reduction area,wound healing rate),oxidative stress indexes of wound[superoxide dismutase(SOD),malondialdehyde(MDA),advanced oxidation protein products(AOPP)],wound exudation indexes[matrix metalloproteinase-2(MMP-2),sterile alpha motif domaincontaining protein 3(Samd-3),tissue inhibitor of metalloproteinase-2(TIMP-2)],bFGF,VEGF,TGF-β_(1)and the incidence of adverse reactions were compared between the 2 groups.Results After treatment,the wound healing time in combined treatment group was shorter than that in photon therapeutic apparatus group,the wound reduction area was larger than that in photon therapeutic apparatus group,and the wound healing rate was higher than that in photon therapeutic apparatus group(P<0.05).After treatment,the SOD levels was increased in both groups,which was higher in combined treatment group than in photon therapeutic apparatus group(P<0.05),while the AOPP and MDA levels were decreased,which were lower in combined treatment group than in photon therapeutic apparatus group(P<0.05).After treatment,the MMP-2 and Samd-3 in both groups were decreased,which were lower in combined treatment group than in photon therapeutic apparatus group(P<0.05),while the TIMP-2 was increased,which was higher in combined treatment group than in photon therapeutic apparatus group(P<0.05).After treatm

关 键 词：湿润烧伤膏 光子治疗仪 糖尿病足溃疡 创面愈合 血清碱性成纤维细胞生长因子 

分 类 号：R986[医药卫生—药品]