缩宫素联合卡前列腺素类药物对瘢痕子宫产妇剖宫产产后出血预防的效果  

Effect of oxytocin combined with carboprost drugs on the prevention of postpartum hemorrhage after cesarean section in women with scarred uterus

作　　者：王晶 廖丹 赵亚田 王雅 WANG Jing;LIAO Dan;ZHAO Yatian;WANG Ya(Department of Obstetrics and Gynecology,Hainan Modern Women and Children’s Hospital,Haikou 571100,China)

机构地区：[1]海南现代妇女儿童医院妇产科,海口571100

出　　处：《西北药学杂志》2024年第3期115-118,共4页Northwest Pharmaceutical Journal

基　　金：海南省卫生计生行业科研项目(编号:19A200181)。

摘　　要：目的探究缩宫素分别联合卡前列甲酯栓及卡前列素氨丁三醇对瘢痕子宫产妇剖宫产产后出血预防的效果。方法随机抽取本院100例瘢痕子宫产妇作为研究对象,用简单随机法分为对照组和试验组,每组50例。对照组给予缩宫素联合卡前列甲酯栓治疗,试验组给予缩宫素联合卡前列素氨丁三醇治疗。比较2组术前、术后2 h的凝血功能[活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、血浆凝血酶时间(thrombin time,TT)和纤维蛋白原(fibrinogen,Fib)],术中及术后2、24 h出血量,宫缩情况,不良反应发生率。结果2组产妇术后2 h的APTT、TT和Fib水平均低于术前(P<0.05),且试验组各水平均低于同期对照组(P<0.05);试验组产妇术中及术后2、24 h出血量均低于对照组(P<0.05);试验组产妇的宫缩良好例数多于对照组(P<0.05);2组产妇的不良反应发生率比较差异无统计学意义(P>0.05)。结论缩宫素分别联合卡前列甲酯栓和卡前列素氨丁三醇均能促进瘢痕子宫产妇再次剖宫产时的子宫收缩,预防产后出血,但缩宫素联合卡前列素氨丁三醇的效果更好,二者的安全性均较高。Objective To explore the preventive effect of oxytocin combined with carboprost methylate suppository or carboprost tromethamine on postpartum hemorrhage in puerperae with scar uterus undergoing cesarean section.Methods 100 puerperae with scar uterus were randomly collected in the hospital as the study subjects,and were divided into control group(n=50)and experimental group(n=50)according to the simple randomization method.The control group was treated with oxytocin combined with carboprost methylate suppository therapy,and the experimental group was given oxytocin combined with carboprost tromethamine therapy.The coagulation function[activated partial thromboplastin time(APTT),plasma thrombin time(TT)and fibrinogen(Fib)]before surgery and at 2 hours after surgery,the hemorrhage volumes during surgery and at 2 hours and 24 hours after surgery,uterine contractions and the incidence rates of adverse reactions were compared between the 2 groups.Results The APTT,TT and Fib in the 2 groups at 2 hours after surgery were shorter or lower than those before surgery(P<0.05),and the above indicators in experimental group were shorter or lower than those in control group(P<0.05).The hemorrhage volumes during surgery and at 2 hours and 24 hours after surgery were less in experimental group than those in control group(P<0.05).The number of cases with good uterine contractions in experimental group was more than that in control group(P<0.05).There was no statistical differences in the incidence rates of adverse reactions between the 2 groups(P>0.05).Conclusion Both oxytocin combined with carboprost methylate suppository or carboprost tromethamine can promote uterine contractions and prevent postpartum hemorrhage in puerperae with scar uterus after repeated cesarean section,but oxytocin combined with carboprost tromethamine has a better effect,and the both methods have high safety.

关 键 词：缩宫素 卡前列甲酯栓 卡前列素氨丁三醇 剖宫产 出血 

分 类 号：R984[医药卫生—药品]