IL-1β和IL-18对重症肺炎的诊断意义  

The diagnostic significance of IL-1βand IL-18 in severe pneumonia

作　　者：张素婷 许银银[1] ZHANG Suting;XU Yinyin(Department of Clinical Laboratory,the Affiliated Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)

机构地区：[1]重庆医科大学附属永川医院检验科,重庆402160

出　　处：《中国现代医生》2024年第13期36-39,78,共5页China Modern Doctor

摘　　要：目的探讨血清白细胞介素(interleukin,IL)-1β和IL-18水平对肺炎严重程度的诊断价值。方法回顾性选取2022年1月至12月于重庆医科大学附属永川医院治疗的肺炎患者200例,根据肺炎严重程度将其分为轻症组(n=100)和重症组(n=100),同时纳入在本院体检的健康人100名作为正常组;统计其一般临床资料、血液学指标、热峰、咳嗽、啰音和并发症等临床症状发生情况。对轻症组和重症组患者进行倾向性评分匹配,采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)计算匹配前后IL-1β、IL-18诊断重症肺炎的效能。结果三组受试者的IL-1β、IL-18水平差异均有统计学意义(P<0.05),且重症组>轻症组>正常组。匹配前IL-1β、IL-18诊断重症肺炎的截断值分别为12.169pg/ml、194.535pg/ml;IL-1β诊断重症肺炎的诊断效能高于IL-18(0.490 vs.0.380)。匹配后IL-1β、IL-18诊断重症肺炎的截断值分别为10.542pg/ml、191.372pg/ml。IL-1β诊断重症肺炎的诊断效能高于IL-18(0.493 vs.0.360)。结论IL-1β和IL-18随着肺炎严重程度而升高,对重症肺炎具有较高的诊断价值。Objective To explore the diagnostic value of serum interleukin(IL)-1βand IL-18 levels in the severity of pneumonia.Methods A total of 200 patients with pneumonia treated in the Affiliated Yongchuan Hospital of Chongqing Medical University from January to December 2022 were retrospectively selected and divided into mild group(n=100)and severe group(n=100)according to the severity of pneumonia,and 100 healthy people who underwent physical examination in our hospital were included as normal group.The general clinical data,hematology index,fever peak,cough,rales and complications were analyzed.Propensity score matching was performed for patients in mild group and severe group,and the receiver operating characteristic(ROC)curve was used to calculate the diagnostic efficacy of IL-1βand IL-18 before and after matching.Results There were statistically significant differences in IL-1βand IL-18 levels among the three groups(P<0.05),and severe group>mild group>normal group.The cut-off values of IL-1βand IL-18 in the diagnosis of severe pneumonia before matching were 12.169pg/ml and 194.535pg/ml,respectively.IL-1βwas more effective than IL-18 in the diagnosis of severe pneumonia(0.490 vs.0.380).The cut-off values of IL-1βand IL-18 in the diagnosis of severe pneumonia after matching were 10.542pg/ml and 191.372pg/ml,respectively.IL-1βwas more effective than IL-18 in the diagnosis of severe pneumonia(0.493 vs.0.360).Conclusion IL-1βand IL-18 increase with the severity of pneumonia and have high diagnostic value for severe pneumonia.

关 键 词：肺炎 白细胞介素-1Β 白细胞介素-18 诊断效能 

分 类 号：R446.5[医药卫生—诊断学]