依替米星联合胸腺肽α1对脓毒症患者肠道菌群、循环功能及肾功能的影响  

Effect of etimicin combined with thymopeptideα1 on intestinal flora,circulatory function and renal function in patients with sepsis

作　　者：张高泽 刘爱娣 陈欢 ZHANG Gaoze;LIU Aidi;CHEN Huan(Department of Emergency Medicine,Wenzhou Central Hospital,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市中心医院急诊医学科,浙江温州325000

出　　处：《中国现代医生》2024年第13期64-67,94,共5页China Modern Doctor

摘　　要：目的 探讨依替米星联合胸腺肽α1对脓毒症患者肠道菌群、循环功能及肾功能的影响。方法 选取2021年3月至2022年6月于温州市中心医院治疗的80例脓毒症患者,根据治疗方式将其分为对照组和研究组,每组各40例。对照组患者在常规治疗的基础上给予胸腺肽α1治疗,研究组患者在对照组治疗的基础上加用依替米星,两组患者均治疗2周。比较两组患者的肠道菌群、循环功能、肾功能、机械通气时间、住院时间、急性生理学和慢性健康状况评价Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分和临床疗效。结果 治疗后,两组患者的双歧杆菌、中心静脉压(central venous pressure,CVP)、平均动脉压(mean arterial pressure,MAP)、尿量均显著高于本组治疗前,肠杆菌、肠球菌、葡萄球菌、类杆菌、专性厌氧菌、假单胞菌、心率、血肌酐、尿素氮均显著低于本组治疗前(P<0.05);研究组患者的双歧杆菌、CVP、MAP均显著高于对照组,肠杆菌、肠球菌、葡萄球菌、类杆菌、专性厌氧菌、假单胞菌、心率、APACHEⅡ评分均显著低于对照组(P<0.05)。研究组患者的机械通气时间、住院时间均显著短于对照组(P<0.05)。研究组患者的治疗总有效率显著高于对照组(χ^(2)=6.275,P=0.012)。结论 依替米星联合胸腺肽α1治疗脓毒症患者,可有效调节患者的肠道菌群和循环功能,且对肾功能的影响较小,值得临床推广应用。Objective To investigate the effect of etimicin combined with thymopeptideα1 on intestinal flora,circulatory function and renal function in patients with sepsis.Methods A total of 80 patients with sepsis treated in Wenzhou Central Hospital from March 2021 to June 2022 were selected and divided into control group and study group according to treatment methods,with 40 cases in each group.The control group was treated with thymopeptideα1 on the basis of conventional treatment,and the study group was treated with etimicin on the basis of control group treatment,and both groups were treated for 2 weeks.The intestinal flora,circulatory function,renal function,mechanical ventilation duration,hospital stay,acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores and clinical efficacy of two groups were compared.Results After treatment,Bifidobacterium,central venous pressure(CVP),mean arterial pressure(MAP)and urine volume of patients in both groups were significantly higher than before treatment,Enterobacter,Enterococcus,Staphylococcus,Bacterioid,Obligate anaerobe,Pseudomonas,heart rate,serum creatinine and blood urea nitrogen were significantly lower than before treatment(P<0.05).Bifidobacterium,CVP and MAP of study group were significantly higher than those of control group,and Enterobacter,Enterococcus,Staphylococcus,Bacterioid,Obligate anaerobe,Pseudomonas,heart rate,and scores of APACHEⅡwere significantly lower than those of control group(P<0.05).The mechanical ventilation time and hospital stay in study group were significantly shorter than those in control group(P<0.05).The total effective rate of study group was significantly higher than that of control group(c2=6.275,P=0.012).Conclusion Etimicin combined with thymopeptideα1 in the treatment of sepsis can effectively regulate the intestinal flora and circulatory function of patients,and has little effect on renal function,which is worthy of clinical promotion and application.

关 键 词：依替米星 胸腺肽Α1 脓毒症 肠道菌群 循环功能 肾功能 

分 类 号：R631[医药卫生—外科学]