益气温阳活血利水法在膜性肾病中的疗效及对相关抗体、凝血纤溶系统的影响  

Effect of Yiqi Wenyang Huoxue Lishui Method in the Treatment of Patients with Membranous Nephropathy and Influence for Related Antibodies,Coagulation and Fibrinolysis Systems

作　　者：林珊珊 李雪 吴蕾[1] 陈烨 LIN Shanshan;LI Xue;WU Lei;CHEN Ye(Beijing Changping District Hospital of Traditional Chinese Medicine,Beijing 102200,China;不详)

机构地区：[1]北京市昌平区中医医院,北京102200

出　　处：《中外医学研究》2024年第10期48-52,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究益气温阳活血利水法在膜性肾病(MN)中的疗效及对相关抗体、凝血纤溶系统的影响。方法:选择2020年6月-2022年6月北京市昌平区中医医院收治的83例MN患者,根据随机数表法分为对照组(n=41)和观察组(n=42)。对照组进行常规MN治疗,观察组则在对照组的基础上加用益气温阳活血利水法进行治疗。比较两组的MN治疗总有效率、治疗前后的症状体征积分(颜面肢体水肿、神疲乏力及畏寒肢冷)、相关抗体指标[血清抗磷脂酶A2受体抗体(PLA2R-Ab)及磷脂酶A2-ⅠB(PLA2-ⅠB)]及凝血纤溶指标[组织纤维溶酶原激活物(t-PA)、纤溶酶原激活抑制剂(PAI-Ⅰ)及活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组症状体征积分、相关抗体指标及凝血纤溶指标比较,差异无统计学意义(P>0.05);治疗1个疗程及2个疗程后,观察组各项症状体征积分均低于对照组,差异有统计学意义(P<0.05)。治疗1个疗程及2个疗程后,观察组PLA2R-Ab、PLA2-ⅠB及PAI-Ⅰ显著低于对照组,t-PA高于对照组,APTT、TT长于对照组,差异有统计学意义(P<0.05)。结论:益气温阳活血利水法应用于MN中的疗效较好,且可有效改善患者相关抗体及凝血纤溶状态。Objective:To explore the effect of Yiqi Wenyang Huoxue Lishui method on membranous nephropathy(MN)and its influence on related antibodies and coagulation and fibrinolytic system.Method:A total of 83 patients with MN treated in Beijing Changping District Hospital of Traditional Chinese Medicine from June 2020 to June 2022 were selected and divided into control group(n=41)and observation group(n=42)according to random number table method.The control group was treated with routine MN,and the observation group was treated with Yiqi Wenyang Huoxue Lishui method on the basis of control group.The total effective rate,symptom and sign scores(facial and limb edema,fatigue and cold limbs)before and after treatment,related antibody indexes[serum anti-phospholipase A2 receptor antibody(PLA2R-Ab)and phospholipase A2-ⅠB(PLA2-ⅠB)],coagulation fibrinolytic indexes[tissue plasminogen activator(t-PA)and proenzyme activation inhibitor(PAI-Ⅰ)and activated partial thromboplastin time(APTT)and thromboplastin time(TT)]were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in symptom and sign scores,related antibody indexes and coagulation and fibrinolysis indexes between the two groups(P>0.05).After 1 course of treatment and 2 courses of treatment,the scores of symptoms and signs in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 1 course of treatment and 2 courses of treatment,PLA2R-Ab,PLA2-IB and PAI-I in observation group were significantly lower than those in control group,while t-PA was higher than that in control group,APTT and TT were longer than those in control group,the differences were statistically significant(P<0.05).Conclusion:The therapeutic effect of Yiqi Wenyang Huoxue Lihui method on MN is good,and it can effectively improve the

关 键 词：益气温阳活血利水法 膜性肾病 疗效 抗体 凝血纤溶系统 

分 类 号：R277.5[医药卫生—中医学]