2型糖尿病患者急性冠心病事件发病风险的回顾性队列研究  

Retrospective cohort study on risk of acute coronary events in patients with type 2 diabetes mellitus

作　　者：樊丽辉[1] 姜雪霞 郑宇航 叶振淼[1] 罗永园 Fan Lihui;Jiang Xuexia;Zheng Yuhang;Ye Zhenmiao;Luo Yongyuan(Institute of Chronic Diseases,Wenzhou Center for Disease Control and Prevention,Wenzhou 325001,China)

机构地区：[1]温州市疾病预防控制中心慢病所,浙江温州325001

出　　处：《中国医院统计》2024年第2期90-94,共5页Chinese Journal of Hospital Statistics

基　　金：温州市科技局项目(Y20210383)。

摘　　要：目的分析2型糖尿病患者急性冠心病事件的发病风险,为糖尿病患者管理提供依据。方法基于温州市慢性病协同管理系统数据进行回顾性队列研究,277205例2010—2020年诊断的新发2型糖尿病患者纳入分析,通过身份证号与急性冠心病事件监测库和死亡监测数据库进行匹配,获得冠心病发病和死亡信息。采用Cox风险回归模型分析糖尿病患者确诊时并发症情况与急性冠心病事件发病风险的关联。结果随访期间共有3241例2型糖尿病患者发生急性冠心病事件,冠心病发病率为1169.17/10万。1083名糖尿病患者因冠心病死亡,病死率390.69/10万。以糖尿病患者确诊时无并发症为参照,1个并发症和2个及以上者冠心病发病风险HR分别为1.382(95%CI:1.266~1.508)和1.661(95%CI:1.221~2.259)。结论2型糖尿病患者急性冠心病事件的发病和死亡风险较高,在患者管理中应加强干预,积极防治并发症发生。Objective To analyze the risk of acute coronary events in patients with type 2 diabetes mellitus,and to provide basis for the management of patients.Methods Based on the data of Wenzhou chronic disease collaborative management system,a retrospective cohort study was conducted.A total of 277205 newly diagnosed type 2 diabetes mellitus patients from 2010 to 2020 were included in the analysis.The incidence and death information were obtained by matching the ID number with the data of acute coronary events and deaths.COX regression model was used to analyze the relationship between the complications of diabetes patients at the time of diagnosis and the risk of acute coronary events.Results During the follow-up period,acute coronary events occurred in 3241 cases,and the incidence rate of coronary heart disease was 1169.17/100000;1083 diabetes patients died from coronary heart disease,with a fatality rate of 390.69/100000.Taking the patients diagnosed without complications as the reference,the HR of acute coronary disease in patients with one complication and two or more was 1.382(95%CI:1.266-1.508)and 1.661(95%CI:1.221-2.259)respectively.Conclusion Type 2 diabetes patients have a high risk of morbidity and mortality from acute coronary events,so intervention should be strengthened in patient management to actively prevent and treat complications.

关 键 词：2型糖尿病 冠心病 队列研究 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]