可控微波促进对称1,n-亚甲基二酯的环境友好合成  

Controlled Microwave-promoted Environmentally Friendly Synthesis of Symmetric 1,n-Methylene Diesters

作　　者：白林[1] 马小芳 BAI Lin;MA Xiaofang(Institute of Green Chemistry Experiment and Teaching,Lanzhou City University,Lanzhou Gansu 730070)

机构地区：[1]兰州城市学院绿色化学实验与教学研究所,甘肃兰州730070

出　　处：《甘肃高师学报》2024年第2期1-6,共6页Journal of Gansu Normal Colleges

摘　　要：采用可控微波加热技术,在水作溶剂或无溶剂条件下芳甲酸与1,n-二溴代烷发生双酯化反应,“一锅”法高效地合成了系列亚甲基二羧酸酯类化合物.考察了反应温度、时间、碱、溶剂对双酯化产率的影响,在优化实验条件下合成了31种亚甲基二羧酸酯,底物适用范围广,并提出了合理的反应机理.该方法操作简单、时间短,产率较高,同时符合绿色化学的原则.A series of methylene dicarboxylic acid esters were efficiently synthesized using controllable microwave heating technology by diesterification of arylformic acid and 1,n-dibromoalkanes in water or without solvent.The "one pot" method was employed,allowing for the synthesis of a diverse range of methylene diester compounds.The effects of reaction temperature,time,alkali and solvent on the yield of diesterification were investigated.Under the optimized experimental conditions,31 kinds of methylene dicarboxylate were synthesized.The substrate was widely application range,and a reasonable reaction mechanism was proposed.The method has the advantage of simple operation,short time,high yield and conforms to the principles of green chemistry.

关 键 词：二溴代烷 亚甲基二酯 无溶剂反应 微波辐射 水相反应 环境友好合成 

分 类 号：O624[理学—有机化学]