磁共振细胞外容积分数联合PDFF成像在NAFLD食蟹猴模型中对早期肝脏纤维化的诊断价值  

Diagnostic Value of MRI-ECV Combined with MRI-PDFF Imaging for Early Liver Fibrosis in a NAFLD Cynomolgus Model

作　　者：芮茂萍[1] 朱晓艳 吕梁[2] 刘兴利 范东[2] 朱正华 RUI Mao-ping;ZHU Xiao-yan;LV Liang;LIU Xing-li;FAN Dong;ZHU Zheng-hua(Department of Magnetic Resonance Imaging,The First People's Hospital of Yunnan Province,The Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,Yunnan Province,China;Department of Radiology,The First People's Hospital of Yunnan Province,The Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,Yunnan Province,China;Kunming Biomed International,Kunming 650500,Yunnan Province,China)

机构地区：[1]云南省第一人民医院,昆明理工大学附属医院磁共振科,云南昆明650032 [2]云南省第一人民医院,昆明理工大学附属医院放射科,云南昆明650032 [3]昆明科灵生物科技有限公司,云南昆明650500

出　　处：《中国CT和MRI杂志》2024年第5期120-122,共3页Chinese Journal of CT and MRI

基　　金：云南省万人计划名医专项(YNWR-MY-2019-011);中华国际医学交流基金会-SKY影像科研基金(Z-2014-07-1912-17)。

摘　　要：目的探讨肝脏磁共振细胞外容积分数(extracellular volume,ECV)及质子密度脂肪分数(proton density fat fraction,PDFF)在非酒精性脂肪性肝病早期肝纤维化(F1期)食蟹猴中的诊断价值｡方法纳入经肝穿病理证实的早期肝纤维化食蟹猴104只(F1期组)和10只健康对照组,对比两组肝ECV和PDFF值差异及对早期肝纤维的诊断效能｡结果F1期组ECV､PDFF值均高于对照组(P<0.001)｡ECV和PDFF与肝NAS评分呈中度相关(rECV-小叶炎症评分=0.432 P<0.001,rPDFF-脂肪变性评分=0.628 P<0.001),ECV在早期肝纤维､PDFF在脂肪定量评估中均具有良好的诊断效能(AUCECV=0.884,P<0.001,AUC-PDFF=0.991,P<0.001)｡结论MRI-ECV联合PDFF成像在NAFLD食蟹猴中对早期肝纤维化及脂肪定量评估具有巨大潜力.Objective To investigate the diagnostic value of magnetic resonance extracellular volume fraction(ECV)and proton density fat fraction(PDFF)in cynomolgus monkey model of nonalcoholic fatty liver disease(NAFLD).Methods 104 cynomolgus monkeys(F1 group)with early liver fibrosis(stage F1)were confirmed by liver puncture pathology and 10 normal cynomolgus monkeys(normal group)were included for abdominal T1 mapping and PDFF imaging.The liver magnetic resonance extracellular volume fraction(MRI-ECV)and the fat fraction of the two groups were compared.Results the MRI-ECV and PDFF value in the F1 group were higher than those in the normal group,and there was significant difference between the two groups(PECV<0.001,PPDFF<0.001).There was a moderate correlation between MRI-ECV and MRI-PDFF with NAS scores of liver(rECV-lobular inflammation=0.432 P<0.001,rPDFFsteatosis=0.628 P<0.001),demonstrating good diagnostic efficacy in liver fibrosis and fat assessment.Conclusion MRI-ECV combined with MRI-PDFF has great potential for quantitative evaluation of early liver fibrosis and fat fraction in NAFLD cynomolgus monkey model.

关 键 词：细胞外容积分数 质子密度脂肪分数 肝脏纤维化 非酒精性脂肪性肝病 食蟹猴 

分 类 号：R445.2[医药卫生—影像医学与核医学]